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Effect of exosome on endometrial thickness

Investigating the Effect of Intrauterine Exosome Injection on Endometrial Thickness, Vascularity, and Fertility Outcomes in Women with Thin Endometrium

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
IRCT
Registry ID
IRCT20251206068228N1
Enrollment
30
Registered
2026-01-07
Start date
2026-01-21
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thin endometrium. Female infertility of uterine origin

Interventions

Intervention 1: Intervention group: Trans cervical intrauterine injection of exosomes under ultrasound guidance Ultrasound-guided intrauterine injection of exosomes derived from mesenchymal stem cells

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 45 Years

Inclusion criteria

Inclusion criteria: Every woman between 20 and 45 Candidate for embryo transfer History of cycle cancelation due to thin endometrium

Exclusion criteria

Exclusion criteria: Age more than 45 History of recurrent abortion Autoimmune disease History of molar pregnancy History of endometriosis surgery

Design outcomes

Primary

MeasureTime frame
Clinical pregnancy. Timepoint: at 6th week ofter LMP(last mensturation period). Method of measurement: Positive fetal heart in transvaginal sonography.;Endometrial thickness. Timepoint: Day 12th-14th mensural cycle. Method of measurement: Transvaginal sonography.;Endometrial perfusion. Timepoint: Day 12th-14th mensural cycle. Method of measurement: Transvaginal doppler sonography.;Positive pregnancy test. Timepoint: 14th day after emberyo transfer. Method of measurement: Blood beta HCG.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDR Hatav Ghasemi Tehrany

Esfahan University of Medical Sciences

hatav.tehrani2014@gmail.com+98 31 3693 2494

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026