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The effect of topical estrogen and platelet-rich plasma in the treatment of genitourinary syndrome of menopause in postmenopausal women.

Comparison of topical estrogen with platelet-rich plasma in the treatment of postmenopausal genitourinary syndrome

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20251205068220N1
Enrollment
90
Registered
2026-02-11
Start date
2026-02-20
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Genitourinary syndrome. Menopausal and other perimenopausal disorders

Interventions

Intervention 1: First intervention group:PRP recipient In this study, a topical anesthetic cream is used to numb the anterior vaginal wall and clitoris, and the PRP injection is performed 20 minutes a

Sponsors

Yasouj University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
45 Years to 70 Years

Inclusion criteria

Inclusion criteria: Postmenopausal women diagnosed with vaginal atrophy

Exclusion criteria

Exclusion criteria: History of any type of vaginal cancer or previous radiotherapy Current use of vaginal lubricants or moisturizers Use of anabolic steroids, systemic estrogen therapy in the past 6 months Abnormal uterine bleeding Acute thrombophlebitis, or previous thromboembolic disorders related to estrogen use within the past 6 months prior to the study Those who have any contraindications to estrogen therapy

Design outcomes

Primary

MeasureTime frame
Urinary tract function. Timepoint: Beginning of the study, weeks 4, 8, and 12. Method of measurement: International consulation on incontinence questionnaire short form and Urogenital distress inventory scale.;Sexual function. Timepoint: Beginning of the study, weeks 4, 8, and 12. Method of measurement: Female sexual function index.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactParand Eskandari

Yasouj University of Medical Sciences

eskandariparand@yahoo.com+98 74 3334 6070

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026