Osteoarthritis. Osteoarthritis, unspecified site
Conditions
Interventions
Intervention 1: Patients will orally take one 500 mg capsule of the herbal medicine (containing dried hydroalcoholic [70% ethanol] extract of Golpar fruit, produced by the Medicinal Plants Research Ce
Sponsors
Iranian academic center for education culture and research
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: Male or female patients aged 40 to 80 years, with grade 1 or 2 knee osteoarthritis according to the American College of Rheumatology criteria. No secondary osteoarthritis (due to a known underlying condition), no history of arthroscopy, surgery, or knee joint replacement, and no history of injection into the target knee joint within the past 6 months. No history of alcohol, drug, or substance abuse, and no diagnosis of fibromyalgia or other disabling conditions affecting the knee.
Exclusion criteria
Exclusion criteria: Pregnant and lactating women. Presence of any serious systemic diseases (such as concurrent infections, cardiovascular, hepatic, or renal diseases) and any other chronic inflammatory conditions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Joint pain. Timepoint: Before the intervention and after 1 and 2 months at the end of the intervention. Method of measurement: The Visual Analogue Scale Questionnaire.;Joint stiffness. Timepoint: Before the intervention and after 1 and 2 months at the end of the intervention. Method of measurement: The Western Ontario and McMaster Universities Arthritis Index Questionnaire.;Physical activity. Timepoint: Before the intervention and after 1 and 2 months at the end of the intervention. Method of measurement: The Western Ontario and McMaster Universities Arthritis Index Questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in kidney function indices and electrolytes (BUN, Cr, Na, K). Timepoint: Before intervention and end of intervention after 2 months. Method of measurement: Venous blood samples will be collected, and serum levels will be measured using spectrophotometry and ion-selective electrode methods.;Changes in hematological parameters (CBC diff, PT, PTT). Timepoint: Before intervention and end of intervention after 2 months. Method of measurement: Venous blood samples will be collected and analyzed using an automated hematology analyzer.;Changes in liver enzymes and liver function indices (AST, ALT, ALP, GGT, Albumin, Bilirubin). Timepoint: Before intervention and end of intervention after 2 months. Method of measurement: Venous blood samples will be collected, and serum parameters will be measured using colorimetric kits and a biochemistry analyzer. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSajad Hosseinzadeh
Bagheiat-allah University of Medical Sciences
Outcome results
None listed