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The effect of dexmedetomidine, ketamine, or fentanyl on postoperative pain intensity after abdominal hysterectomy

Comparison of the effect of adding dexmedetomidine, ketamine, or fentanyl in PCA (patient-controlled analgesia) pump combinations on postoperative pain intensity and the incidence of complications in patients undergoing abdominal hysterectomy

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20251202068195N1
Enrollment
99
Registered
2026-01-07
Start date
2026-01-10
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

anesthesiology. Acute pain, not elsewhere classified

Interventions

Intervention 1: Intervention Group 1: This group will receive patient-controlled analgesia (PCA) via auto-infusion pump postoperatively. The PCA solution will contain 3 grams of acetaminophen, 8 milli

Sponsors

Iran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Age range 18-60 years American Society of Anesthesiologists(ASA) Class I-III Having full consent to enter the study A candidate for abdominal hysterectomy

Exclusion criteria

Exclusion criteria: History of allergy to any of the drugs used in the study History of kidney or liver failure Obesity and Body mass index greater than 35 Pregnancy and lactation Addiction to any type of narcotics or substance abuse History of psychiatric or neurological disorders Uncontrolled hypertension Patients with a history of seizures Bradycardia and cardiac conduction block

Design outcomes

Primary

MeasureTime frame
Pain severity. Timepoint: Upon arrival in the recovery room and at 2, 6, 12, and 24 hours after receiving pain pumps. Method of measurement: The Numerical Rating Scale (NRS).;Incidence of complications. Timepoint: Upon arrival in the recovery room and at 2, 6, 12, and 24 hours after receiving pain pumps. Method of measurement: Interview and physical examination.

Secondary

MeasureTime frame
Patient satisfaction. Timepoint: 24 hours postoperatively after receiving the pain pumps. Method of measurement: Likert Scale scoring system.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNegin Mousavi

Iran University of Medical Sciences

negin.mousavi.1373@gmail.com+98 21 8214 1000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026