The effect of topical melatonin combined with xenogeneic bone graft powder on bone formation and the width of keratinized gingiva in the extraction site.

The effect of using melatonin hormone locally along with xenograft on bone regeneration and improving the quality of soft tissue in the extracted tooth area

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20251201068171N1

Enrollment

Registered

2026-01-30

Start date

2026-01-20

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental socket preservation.

Interventions

Intervention 1: Intervention group: In the intervention group, following tooth extraction, the extraction socket is filled with xenograft bone powder combined with melatonin.This study is designed as

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Patients with non-restorable teeth who are candidates for implant treatment

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Primary Outcome Variable Description:The primary outcome variable is the amount of newly formed bone in the dental socket after using melatonin combined with xenograft compared to xenograft alone. Timepoint: Time Points of Measurement: 1. Baseline (before tooth extraction / intervention): Measurement of attached gingiva thickness as a reference for soft tissue evaluation 2. Immediately after material placement in the dental socket: Initial clinical observations recorded 3. Week 1 and Week 2 post-surgery: Clinical follow-up including suture closure, swelling, infection, and unpleasant odor 4. Two months post-surgery: • Bone sampling from both intervention and control sites before implant placement • Radiographic assessment to evaluate bone status and structural changes. Method of measurement: The bone formation is measured using histological analysis (histomorphometry) or image analysis software (Image-Pro Plus) • Results are reported as the percentage of new bone relative to the total tissue section area.;The secondary outcome variable is attached gingiva thickness around the dental socket, reflecting soft tissue changes after using melatonin combined with xenograft compared to xenograft alone. Timepoint: 1. Baseline (before tooth extraction / intervention): Measurement of attached gingiva thickness using a periodontal probe 2. Immediately after material placement in the dental socket: Recording initial clinical observations of the gingiva 3. Week 1 and Week 2 post-surgery: Clinical assessment of the gingiva, including swelling, inflammation, and soft tissue healing 4. Two months post-surgery: Re-measurement of attached gingiva thickness to evaluate soft tissue changes. Method of measurement: Measurements are performed using a periodontal probe and recorded at predefined time points.	—

Measure

Time frame

Primary Outcome Variable Description:The primary outcome variable is the amount of newly formed bone in the dental socket after using melatonin combined with xenograft compared to xenograft alone. Timepoint: Time Points of Measurement: 1. Baseline (before tooth extraction / intervention): Measurement of attached gingiva thickness as a reference for soft tissue evaluation 2. Immediately after material placement in the dental socket: Initial clinical observations recorded 3. Week 1 and Week 2 post-surgery: Clinical follow-up including suture closure, swelling, infection, and unpleasant odor 4. Two months post-surgery: • Bone sampling from both intervention and control sites before implant placement • Radiographic assessment to evaluate bone status and structural changes. Method of measurement: The bone formation is measured using histological analysis (histomorphometry) or image analysis software (Image-Pro Plus) • Results are reported as the percentage of new bone relative to the total tissue section area.;The secondary outcome variable is attached gingiva thickness around the dental socket, reflecting soft tissue changes after using melatonin combined with xenograft compared to xenograft alone. Timepoint: 1. Baseline (before tooth extraction / intervention): Measurement of attached gingiva thickness using a periodontal probe 2. Immediately after material placement in the dental socket: Recording initial clinical observations of the gingiva 3. Week 1 and Week 2 post-surgery: Clinical assessment of the gingiva, including swelling, inflammation, and soft tissue healing 4. Two months post-surgery: Re-measurement of attached gingiva thickness to evaluate soft tissue changes. Method of measurement: Measurements are performed using a periodontal probe and recorded at predefined time points.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahdi Nozhati Maleki

Tabriz University of Medical Sciences

Mahdinozhati2002@gmail.com+98 41 3784 2502

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026