The effects of IV injectable dexamethasone and methylprednisolone succinate in controlling asthma attacks in children aged 5 to 15 years

Evaluation and comparison of the effects of IV injectable dexamethasone and methylprednisolone succinate in controlling asthma attacks in children aged 5 to 15 years

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20251201068170N1

Enrollment

100

Registered

2025-12-16

Start date

2026-02-14

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Having an asthma attack. Severe persistent asthma with (acute) exacerbation

Interventions

Intervention 1: Intervention group 1: Standard treatment + injectable dexamethasone 0.15 mg/kg every 12 hours. Intervention 2: Second intervention group: Standard treatment + injectable dexamethasone

Eligibility

Sex/Gender

All

Age

5 Years to 15 Years

Inclusion criteria

Inclusion criteria: Having an asthma attack Informed consent to participate in the study Age 5 to 15 years No history of lung or heart disease Absence of any disease that could affect the results, such as viral or bacterial airway infections

Exclusion criteria

Exclusion criteria: Unwillingness to continue participating in the study Concurrent diagnosis of bronchiolitis, pneumonia, or croup

Design outcomes

Primary

Measure	Time frame
Mean Pediatric Respiratory Assessment Measure (PRAM). Timepoint: 1, 4, 24, 48 hours after the intervention. Method of measurement: Pediatric Respiratory Assessment Measure ((PRAM)Pediatric Respiratory Assessment Measure).;Mean blood oxygen saturation. Timepoint: 1, 4, 24, 48 hours after the intervention. Method of measurement: Pulse oximetry device.;Whistling percentage. Timepoint: 1, 4, 24, 48 hours after the intervention. Method of measurement: Stethoscope.;Percentage of shortness of breath. Timepoint: 1, 4, 24, 48 hours after the intervention. Method of measurement: Checklist.;Percentage of tachypnea. Timepoint: 1, 4, 24, 48 hours after the intervention. Method of measurement: Checklist.	—

Measure

Time frame

Mean Pediatric Respiratory Assessment Measure (PRAM). Timepoint: 1, 4, 24, 48 hours after the intervention. Method of measurement: Pediatric Respiratory Assessment Measure ((PRAM)Pediatric Respiratory Assessment Measure).;Mean blood oxygen saturation. Timepoint: 1, 4, 24, 48 hours after the intervention. Method of measurement: Pulse oximetry device.;Whistling percentage. Timepoint: 1, 4, 24, 48 hours after the intervention. Method of measurement: Stethoscope.;Percentage of shortness of breath. Timepoint: 1, 4, 24, 48 hours after the intervention. Method of measurement: Checklist.;Percentage of tachypnea. Timepoint: 1, 4, 24, 48 hours after the intervention. Method of measurement: Checklist.

—

Secondary

Measure	Time frame
Mean length of stay. Timepoint: After the intervention. Method of measurement: Checklist.;Asthma recurrence percentage. Timepoint: During the study. Method of measurement: Checklist.;Readmission percentage. Timepoint: After studying. Method of measurement: Checklist.;Admission to the intensive care unit. Timepoint: During the study. Method of measurement: Checklist.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactJavad Fadaei Tehrani

Shahre-kord University of Medical Sciences

fadaee.t.j@gmail.com+98 38 3222 0016

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026