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Sodium valproate and cinnarizine in children with migraine.

Comparing the Effects and Side Effects of Sodium Valproate and Cinnarizine on Migraine Attacks and Quality of Life in Children Aged 6 to 14 Years: A Single-Blind Clinical Trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20251123068096N1
Enrollment
142
Registered
2025-12-12
Start date
2026-01-10
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Migraine. Migraine without aura

Interventions

Intervention 1: Intervention group 1: For the sodium valproate group, 15 mg by weight twice a day was given. The first follow-up visit will be 2 weeks after the start of the treatment phase to confirm

Sponsors

Yasouj University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
6 Years to 14 Years

Inclusion criteria

Inclusion criteria: Having the diagnostic criteria for pediatric migraine (with or without aura) defined by the International Headache Society (IHS) with expert opinion

Exclusion criteria

Exclusion criteria: Having a history of cluster headaches

Design outcomes

Primary

MeasureTime frame
Quality of life. Timepoint: 4 weeks before the start of the intervention, 4, 8, and 12 weeks after the intervention. Method of measurement: Children's Quality of Life Questionnaire.;Pain. Timepoint: 4 weeks before the start of the intervention, 4, 8, and 12 weeks after the intervention. Method of measurement: VAS scale.;Drowsiness. Timepoint: 4 weeks before the start of the intervention, 4, 8, and 12 weeks after the intervention. Method of measurement: CSHQ questionnaire.;Duration of migraine attacks. Timepoint: 4 weeks before the start of the intervention, 4, 8, and 12 weeks after the intervention. Method of measurement: Parent child observations per minute.;Number of migraine attacks. Timepoint: 4 weeks before the start of the intervention, 4, 8, and 12 weeks after the intervention. Method of measurement: Observations of the child's parent.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBahram Mohammadi

Yasouj University of Medical Sciences

rmohammdi114@yahoo.com+98 74 3323 5153

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026