The effect of the combination of sufentanil-dexmedetomidine and remifentanil-acetaminophen in pain control after knee replacement surgery.

Comparison of the effect of the combination of Sufentanil, Dexmedetomidine and Remifentanil Acetaminophen as patient controlled analgesia in postoperative pain control in candidates of Total Knee Arthroplasty

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20251123068087N1

Enrollment

100

Registered

2025-12-09

Start date

2025-12-11

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee replacement surgery. Osteoarthritis of knee

Interventions

Intervention 1: First intervention group: In this group, 50 patients will receive dexmedetomidine 100 micrograms (Exir-Iran) and sufentanil 50 micrograms (Abo Raihan-Iran) dissolved in 100 ml of norma

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Performing spinal anesthesia in surgery Age 20 to 60 years

Exclusion criteria

Exclusion criteria: Allergy to drugs used in the study

Design outcomes

Primary

Measure	Time frame
Patient's knee pain. Timepoint: 2, 12 and 24 hours after surgery. Method of measurement: Visual Analogue Scale of pain.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmirhosein Khaknejad

Arak University of Medical Sciences

amirhoseinkhaknejad@gmail.com+98 86 3457 3305

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026