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Investigating the effect of platelet-rich plasma on the healing process of nasal polyps

Investigating the effect of platelet-rich plasma on the healing process of nasal polyps: Pilot phase of a clinical trial study

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
IRCT
Registry ID
IRCT20251122068073N1
Enrollment
40
Registered
2025-12-06
Start date
2025-12-21
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

nasal polyp. Polyp of nasal cavity

Interventions

Intervention group:Participants in the intervention group receive intranasal injections of autologous platelet-rich plasma (PRP), prepared from each participant’s own blood and administered at the des

Sponsors

Ahvaz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: People who have been diagnosed with nasal polyps by a doctor and can use these drops in addition to routine treatments.

Exclusion criteria

Exclusion criteria: People who, in addition to nasal polyps, have other diseases such as asthma or nose and throat infections.

Design outcomes

Primary

MeasureTime frame
The primary outcome of this study is the change in nasal polyp size and severity following treatment with the study nasal drops. This variable reflects the therapeutic efficacy of the intervention and includes reduction in polyp volume, improvement in nasal obstruction, and alleviation of associated symptoms. Timepoint: Baseline (before starting treatment)•2 weeks after treatment initiation•4 weeks after treatment initiation•8 weeks after treatment (for long-term follow-up, if applicable). Method of measurement: •Clinical assessment using nasal endoscopy and scoring of polyp size according to standardized scales such as the Lildholdt scoring system.•Documentation of endoscopic images and approximate polyp volume measurement.•Patient-reported symptom scoring (e.g., nasal obstruction, rhinorrhea, and olfactory dysfunction) using validated questionnaires.

Countries

Iran (Islamic Republic of)

Contacts

Public Contactmehdi torabizadeh

Ahvaz University of Medical Sciences

drtorabizadeh@ajums.ac.ir+98 916 113 4212

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026