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Comparison of the effect of intravenous caffeine, dexamethasone and aminophylline injection on headache after spinal anesthesia in patients undergoing section surgery

Comparison of the effect of intravenous caffeine, dexamethasone and aminophylline injection on headache after spinal anesthesia in patients undergoing section surgery

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20251121068066N6
Enrollment
140
Registered
2025-12-27
Start date
2025-05-22
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Headache. Drug-induced headache, not elsewhere classified

Interventions

Intervention 1: Intervention group: Caffeine Group: Participants receive intravenous caffeine at a dose of 500 mg diluted in 500 mL normal saline, administered immediately after delivery and placental

Sponsors

Yasouj University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: No prior history of spinal anesthesia or post-dural puncture headache (PDPH). Spinal anesthesia performed by an anesthesiologist using the same needle size and with only one puncture attempt. No history of migraine headaches. No contraindications to the study medications (caffeine, dexamethasone, or aminophylline). Patients undergoing cesarean section with spinal anesthesia at Imam Sajjad Hospital in Yasuj.

Exclusion criteria

Exclusion criteria: Known allergy or contraindication to any of the study medications. Use of additional oral or injectable analgesics during the study period. Presence of headache prior to the surgery. Withdrawal from participation or unwillingness to continue cooperation.

Design outcomes

Primary

MeasureTime frame
Post-spinal anesthesia headache severity measured using the 0–10 cm Visual Analogue Scale (VAS), where 0 indicates no pain and 10 indicates worst pain. Pain intensity is categorized as mild (1–3), moderate (4–7), or severe (8–10). Timepoint: 24 hours after surgery. Method of measurement: Measurement method: Headache intensity is assessed using a 10-cm Visual Analogue Scale (VAS), where the patient marks their pain level. Scores are recorded by the researcher.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAkvan Paymard

Shahid Beheshti Hospital, Yasuj

Akvan_paimard9@yahoo.com+98 917 320 1908

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026