Condition 1: ?Surgical site infection (SSI). Condition 2: Antibiotic-related side effects. Infection following a procedure
Conditions
Interventions
Intervention 1: Intervention Group 1 (Group A): Receiving a single dose of cefazolin 2 g intravenously, one hour before surgery. Intervention 2: Intervention Group 2 (Group B): Receiving a single dose
Sponsors
Dr. Mohamed Amin Ghobadifar
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients who are elective candidates for abdominoplasty. Age between 18 and 65 years. American society of anesthesiologists classification (ASA) class I or II. Willingness to participate in the clinical trial.
Exclusion criteria
Exclusion criteria: History of repeat abdominoplasty. History of allergy or hypersensitivity to cephalosporins (e.g., cephalexin) or penicillins. Need for preoperative antibiotic administration due to conditions such as underlying infection or valvular heart disease. Immunodeficiency caused by diseases such as AIDS and malignancies, or by medications such as corticosteroids and immunosuppressive drugs. History of steroid use. Presence of chronic kidney disease, peripheral vascular disease, uncontrolled hypertension, or pulmonary disease. History of radiotherapy. Chronic skin disease. Recent surgery. American society of anesthesiologists classification (ASA) class III or higher. Refusal to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of surgical site infection (SSI). Timepoint: All patients are followed up for 30 days after surgery to assess infections. This includes weekly in-person evaluations by the surgeon and phone calls every 3 days to document the patients’ status. Method of measurement: 1.Observation of infection with purulent discharge from the wound. 2.If there is discharge, a microbiological culture of fluids or tissue obtained from the wound incision is positive. 3.Pain, tenderness, swelling, redness, and/or warmth occurs in the wound area. 4.The wound infection is diagnosed based on the surgeon’s clinical judgment.;Side effects of antibiotics (such as diarrhea, nausea, skin rashes). Timepoint: All patients are followed up for 30 days after surgery to assess antibiotic-related side effects. This includes weekly in-person evaluations by the surgeon and phone calls every 3 days to document the patients’ status. Method of measurement: Evaluations will perform by a physician. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Mehrdad Mirzaee Rozbahani
Lorestan University of Medical Science
Outcome results
None listed