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Comparison of Bethanechol and Domperidone in the treatment of pediatric feeding intolerance

Comparative effect of bethanechol and domperidone in patients with feeding intolerance

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20251121068063N1
Enrollment
214
Registered
2025-12-02
Start date
2025-11-24
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Oral Feeding Intolerance. Malabsorption due to intolerance, not elsewhere classified

Interventions

Intervention 1: Intervention group1: Patients in this group receive the drug Bethanechol. The method of administration is oral. The dose of the drug is calculated based on 0.5 mg per kilogram of body

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
1 Months to 18 Years

Inclusion criteria

Inclusion criteria: Patients aged 1 month to 18 years Admitted to the Pediatric Intensive Care Unit (PICU) Development of feeding intolerance after initiation of oral feeding Absence of reversible causes for feeding intolerance (such as electrolyte imbalance, constipation, or ileus)

Exclusion criteria

Exclusion criteria: Presence of Gastrointestinal bleeding Necrotizing Enterocolitis (NEC) Mechanical bowel obstruction Hirschsprung’s disease Presence of Electrolyte disturbances Presence of Constipation Presence of Ileus

Design outcomes

Primary

MeasureTime frame
Nutritional tolerance. Timepoint: Daily. Method of measurement: Examination of abdominal distension and discharge by physician/evaluator.

Secondary

MeasureTime frame
Drug side effects. Timepoint: Every week. Method of measurement: Questioning the patient (or parents) and clinical observation to record symptoms and possible side effects.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSara Shoja sangchuli

Mashhad University of Medical Sciences

sara_shoja94@yahoo.com+98 915 419 9748

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026