Comparison of the effects of intravenous and systemic antibiotics in head and neck cancer surgery

Comparison of the Effect of Intravenous Versus Intraincisional Antibiotics on Surgical Site Infection and Related Complications in Patients with Head and Neck Skin Cancer : A Randomized Controlled Trial (RCT)

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20251116068008N1

Enrollment

Registered

2026-05-05

Start date

2026-05-22

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

surgical site infection.

Interventions

Intervention group:.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients with head and neck skin cancer undergoing surgery Having provided written informed consent to participate in the study With no history of allergy to the antibiotics used in the study

Exclusion criteria

Exclusion criteria: Patients with a history of systemic diseases affecting wound healing (such as uncontrolled diabetes) Individuals with immune deficiency Patients who have not adhered to the treatment protocol

Design outcomes

Primary

Measure	Time frame
Incidence of surgical site infection at the incision site of head and neck skin cancer surgery within 30 days after surgery, based on clinical assessment on postoperative days 1, 3, 7, and 30, considering signs of infection including incision site redness, discharge or pus, pain at the surgical site, wound dehiscence, fever above 38°C, need for readmission or additional treatment, and culture result if performed. Timepoint: Postoperative days 1, 3, 7, and 30. Method of measurement: Clinical examination of the surgical incision site by a physician and completion of the wound status and complications follow-up form, including assessment of incision site redness, discharge or pus, pain at the surgical site, wound dehiscence, fever above 38°C, need for readmission or additional treatment, and culture result if performed.	—

Measure

Time frame

Incidence of surgical site infection at the incision site of head and neck skin cancer surgery within 30 days after surgery, based on clinical assessment on postoperative days 1, 3, 7, and 30, considering signs of infection including incision site redness, discharge or pus, pain at the surgical site, wound dehiscence, fever above 38°C, need for readmission or additional treatment, and culture result if performed. Timepoint: Postoperative days 1, 3, 7, and 30. Method of measurement: Clinical examination of the surgical incision site by a physician and completion of the wound status and complications follow-up form, including assessment of incision site redness, discharge or pus, pain at the surgical site, wound dehiscence, fever above 38°C, need for readmission or additional treatment, and culture result if performed.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHesan Abbasi

Islamic Azad University

hesan.abbasi96@gmail.com+98 21 8847 7253

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026