The effect of bupropion on improving cognitive deficits

Investigation of the effect of bupropion on improving cognitive deficits in patients with bipolar disorder in the depressive phase.

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20251112067974N1

Enrollment

Registered

2025-11-30

Start date

2025-12-01

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bipolar disorder in the depressive phase. Bipolar disorder, current episode depressed, moderate

Interventions

Intervention 1: Intervention group: Initially, the purpose and method of the study are explained to each patient. After receiving written consent, patients are asked to complete the DSM-5 bipolar diso

Eligibility

Sex/Gender

All

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Having bipolar disorder (in the depressive phase) Age between 18 and 45 years old No history of receiving RTMS No liver disease or abnormal liver function test results A score above 20 on the MADRS depression scale

Exclusion criteria

Exclusion criteria: History of other psychiatric disorders Pregnancy and breastfeeding Suicidal ideation Drug use (opium/methamphetamine/alcohol) Thyroid disorders History of receiving ECT in the last three months Delirium during diagnostic tests Significant cognitive impairment such as dementia Currently receiving psychiatric interventions such as CBT

Design outcomes

Primary

Measure	Time frame
Sustained attention. Timepoint: To investigate the effect of bupropion on improving cognitive deficits in patients with bipolar disorder in the depressive phase. Patients completed cognitive assessments using the desired tests at the beginning of the study and 8 weeks after the end of the intervention. Method of measurement: Continuous Performance Test (CPT).;Working memory. Timepoint: To investigate the effect of bupropion on improving cognitive deficits (working memory) in patients with bipolar disorder in the depressive phase. Patients completed cognitive assessments using the desired tests at the beginning of the study and 8 weeks after the end of the intervention. Method of measurement: Digit Span Test.;Verbal learning. Timepoint: To investigate the effect of bupropion on improving cognitive deficits (verbal learning) in patients with bipolar disorder in the depressive phase. Patients completed cognitive assessments using the desired tests at the beginning of the study and 8 weeks after the end of the intervention. Method of measurement: Hopkins Verbal Learning Test-Revised (HVLT-R).;Reasoning and problem solving. Timepoint: To investigate the effect of bupropion on improving cognitive deficits (reasoning and problem solving) in patients with bipolar disorder in the depressive phase. Patients completed cognitive assessments using the desired tests at the beginning of the study and 8 weeks after the end of the intervention. Method of measurement: Neurocognitive Assessment Mazes Test (NAB Mazes).	—

Measure

Time frame

Sustained attention. Timepoint: To investigate the effect of bupropion on improving cognitive deficits in patients with bipolar disorder in the depressive phase. Patients completed cognitive assessments using the desired tests at the beginning of the study and 8 weeks after the end of the intervention. Method of measurement: Continuous Performance Test (CPT).;Working memory. Timepoint: To investigate the effect of bupropion on improving cognitive deficits (working memory) in patients with bipolar disorder in the depressive phase. Patients completed cognitive assessments using the desired tests at the beginning of the study and 8 weeks after the end of the intervention. Method of measurement: Digit Span Test.;Verbal learning. Timepoint: To investigate the effect of bupropion on improving cognitive deficits (verbal learning) in patients with bipolar disorder in the depressive phase. Patients completed cognitive assessments using the desired tests at the beginning of the study and 8 weeks after the end of the intervention. Method of measurement: Hopkins Verbal Learning Test-Revised (HVLT-R).;Reasoning and problem solving. Timepoint: To investigate the effect of bupropion on improving cognitive deficits (reasoning and problem solving) in patients with bipolar disorder in the depressive phase. Patients completed cognitive assessments using the desired tests at the beginning of the study and 8 weeks after the end of the intervention. Method of measurement: Neurocognitive Assessment Mazes Test (NAB Mazes).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactFahimeh Omidi

Arak University of Medical Sciences

Dromidi.ac@gmail.com+98 86 3313 4057

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026