Skip to content

Effectiveness of metformin in the treatment of cognitive deficits

Evaluating the effectiveness of metformin in the treatment of cognitive deficits in euthymic adults with bipolar disorder and overweight

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20251112067970N1
Enrollment
64
Registered
2025-11-30
Start date
2025-12-06
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cognitive deficits. Cognitive deficits following unspecified cerebrovascular disease

Interventions

Intervention 1: Intervention group: Sampling was performed by the researcher using random and permuted random block methods from discharged patients from the psychiatric ward of Amirkabir Hospital and

Sponsors

Arak University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Age between 18 and 64 years A diagnosis of bipolar disorder is one that is diagnosed by a medical professional using the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V TR) and does not meet the criteria for any of the mood episodes of depression, mania, or hypomania. BMI above 25

Exclusion criteria

Exclusion criteria: Not pregnant Absence of acute physical illness No history of taking metformin and medications used to treat cognitive disorders (cholinesterase inhibitors and memantine)

Design outcomes

Primary

MeasureTime frame
Cognitive deficits score is measured by the Alzheimer's Disease Assessment Scale - cognitive subscale at baseline and at weeks 6 and 12 to assess the effectiveness of the drug regimen. Timepoint: At the beginning of the study and at weeks 6 and 12. Method of measurement: Alzheimer's Disease Assessment Scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactParisa Rajabi

Arak University of Medical Sciences

drparisarajabi@gmail.com+98 86 3313 1565

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026