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Clinical effects of mechanical cough assistance in ventilated ICU patients

Effect of a cough assist device on hemodynamic status and oxygen saturation in mechanically ventilated adult patients with pneumonia adimitted to the pulmonary intensive care unit

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20251111067960N1
Enrollment
90
Registered
2025-11-23
Start date
2025-11-22
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pneumonia in mechanically ventilated patients.

Interventions

Intervention 1: Control Group: Patients in the control group received only the routine hospital physiotherapy, which consisted of postural drainage, percussion, vibration, and coughing. These interven

Sponsors

Iran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: ICU admitted patiens with at lest 18 years of age Confirmed pneumonia in chest x ray or positive sputum culture Intubated patients who are mechanically ventilated for at least 24 hours Presence of tracheal tube in patient's airway Absence of pneumothorax within a month prior to the study

Exclusion criteria

Exclusion criteria: Presence diaphragmatic hernia Patients with a history of thorasic surgery Patients with recent history of upper GI surgery Patients with primary neuromuscular disease Patients with pneumothorax in the presence of a chest tube Lack of patient consent

Design outcomes

Primary

MeasureTime frame
Arterial oxygen saturation is measured using a pulse oximeter. Timepoint: One hour before the intervention and daily for five days afterwards. Method of measurement: Pulse oximeter.;Hemodynamic status, including heart rate and respiratory rate, is assessed by the ventilator. Timepoint: One hour before the intervention and daily for five days afterwards. Method of measurement: Ventilator.;Tidal volume. Timepoint: One hour before the intervention and daily for five days afterwards. Method of measurement: Ventilator.;Dynamic compliance. Timepoint: One hour before the intervention and daily for five days afterwards. Method of measurement: Ventilator.;Venous partial pressure of oxygen. Timepoint: One hour before the intervention and daily for five days afterwards. Method of measurement: Venous blood gas lab test.;Venous partial pressure of carbon dioxide. Timepoint: One hour before the intervention and daily for five days afterwards. Method of measurement: Venous blood gas lab test.;Respiratory arterial blood gas status in patients before and after treatment. Timepoint: Before treatment and a day after treatment. Method of measurement: Venous blood gas.;The volume and quality of patient's pulmonary secretions are assessed during suctioning. Timepoint: After intervention. Method of measurement: Collection of secretions in a sterile container.;The duration of mechanical ventilation and intubation, as well as the length of stay in the intensive care unit, are recorded. Timepoint: Since the start of study. Method of measurement: Recording in patient files.;The percentage of patients weaned from the ventilator and the percentage of intubated patients successfully extubated. Timepoint: Since the start of study. Method of measurement: Patients counting.;Successfully extubating. Timepoint: Since the start of study until 48 hours after extubation. Method of measurement: Recording patient count.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAfrouz Kargaran Dehkordi

Iran University of Medical Sciences

drkargaran@yahoo.com+98 38 3333 7754

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026