Effect of Vitamin D on Thalassemia Major patient's Liver

Response Rate to Standard Treatment of Vitamin D Deficiency in Major Thalassemia Patients Considering Liver Iron Overload Levels

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20251110067940N1

Enrollment

232

Registered

2025-11-19

Start date

2025-11-22

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Major Thalassemia. Thalassemia

Interventions

Intervention Group: All participants with vitamin D deficiency will receive the same therapeutic intervention. The intervention consists of oral vitamin D3 (Cholecalciferol) manufactured by Zahravi Ph

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Deffinite Diagnosis of Thalassemia Major

Exclusion criteria

Exclusion criteria: Severe Liver Dysfunction Not Attributable to Liver Iron Overload

Design outcomes

Primary

Measure	Time frame
Vitamin D level. Timepoint: It has been scheduled to perform assessments at baseline and at 3- and 6-month intervals for intermediate and final evaluations. Method of measurement: blood sample.;Severity of Liver iron overload. Timepoint: It has been scheduled to perform assessments at baseline and at 6-month intervals for final evaluations. Method of measurement: *Magnetic Resonance Imaging T2.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactGelareh Jalalvand

Karaj University of Medical Sciences

gelareh28@gmail.com+98 26 3250 7633

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026