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the therapeutic effect of topical tofacitinib on facial rosacea lesions

Evaluation of the therapeutic effect of topical tofacitinib ointment 2% on facial rosacea lesions compared tometronidazole gel 0.75%

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20251109067935N1
Enrollment
48
Registered
2025-12-17
Start date
2025-12-05
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

rosacea. Rosacea

Interventions

Intervention group: Using topical tofacitinib ointment 2%.

Sponsors

Tehran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 55 Years

Inclusion criteria

Inclusion criteria: Having rosacea Understanding and informed consent

Exclusion criteria

Exclusion criteria: Pregnancy and breastfeeding use of beta-blockers and calcium channel blockers use of other standard treatments simultaneously or within the last three months Complications due to taking prescribed medication Study

Design outcomes

Primary

MeasureTime frame
Reducing the severity of erythema and flushing. Timepoint: Measurements are taken at four stages (first visit and before starting treatment, one month after starting treatment, then in the third month of taking the drug and one month after stopping treatment). Method of measurement: The severity of erythema will be measured by the physician based on the criteria. On the other hand, the assessment of erythema and flushing will be carried out by the patients themselves based on the CEA Assessment Scale (CEA). Also, using the global flushing severity score (GFSS) and the Patient’s self assessment (PSA) criteria, delta L and delta E will be measured by the Visioface device. Photos of the patients will be taken at all visits and the criteria will be established.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Safoura Shakoeinejad

Tehran University of Medical Sciences

dr.shakoei@gmail.com+98 21 6119 2655

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026