Hyperuricemia. Hyperuricemia without signs of inflammatory arthritis and tophaceous disease
Conditions
Interventions
Intervention 1: Intervention group: They will receive allopurinol at an initial dose of 100 mg/day, with dose adjustment based on serum uric acid levels and tolerance, up to a maximum dose of 300 mg/d
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Adult patients 18 years and older Hyperuricemia with serum uric acid level = 7 mg/dL Having written informed consent to participate in the study Previously untreated patients or those currently receiving stable doses of allopurinol or febuxostat prior to enrollment
Exclusion criteria
Exclusion criteria: History of severe allergic reactions or intolerance to allopurinol or febuxostat History of kidney failure or end-stage kidney disease requiring dialysis History of liver failure or active liver disease History of cardiovascular events in the past 6 months (e.g. myocardial infarction, stroke) History of diuretics, aspirin >325 mg/day, corticosteroids in the past 3 months Suffering from various types of malignancies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to reach target uric acid level of less than 6 mg/dL. Timepoint: At the beginning of the study (before the intervention) and 2 months after the intervention. Method of measurement: Serum uric acid levels were measured from venous blood samples after at least 8 hours of fasting. | — |
Secondary
| Measure | Time frame |
|---|---|
| Frequency and severity of gout flare-ups. Timepoint: Before and 3 months after the intervention. Method of measurement: The frequency of gout flares was recorded based on the number of acute attacks reported by the patient during the follow-up period. The severity of each attack was measured using a numerical pain scale (VAS from 0 to 10) and clinical assessment of joint inflammatory symptoms by the attending physician. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMahboobeh Shirzad
Shahid Beheshti University of Medical Sciences
Outcome results
None listed