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Comparison of Root Canal Irrigation Methods on Postoperative Pain

Comparison of the Effect of XP-Endo Finisher and Passive Ultrasonic Irrigation on Postoperative Pain in Mandibular Molars with Irreversible Pulpitis: A Randomized Controlled Clinical Trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20251106067892N1
Enrollment
69
Registered
2025-11-21
Start date
2025-11-22
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Irreversible pulpitis in mandibular molars without periapical disease. Pulpitis

Interventions

Intervention 1: Control group A: "Final irrigation with 5 mL 5.25% NaOCl using Side-Vented needle for 3 minutes. Intervention 2: Intervention group B :Irrigation with 5 mL 5.25% NaOCl using Side-Vente

Sponsors

Birjand University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Age 18 to 50 years. Mandibular molar tooth with irreversible pulpitis (confirmed by diagnostic tests such as cold test and percussion). Absence of systemic diseases No consumption of anti-inflammatory drugs in the 48 hours prior to treatment Ability to perform root canal treatment in a single session. Providing informed consent for participation in the study.

Exclusion criteria

Exclusion criteria: Presence of symptoms such as abscess, fistula, or periapical radiolucency Consumption of any analgesic medication up to 8 hours prior to treatment. Consumption of alcohol or narcotic substances. Allergy to local anesthesia Pregnancy or breastfeeding. Significant medical history such as uncontrolled diabetes, renal failure, or active autoimmune diseases. Presence of another tooth with pulpal issues on the same side or opposite side. Teeth with root surface caries, root resorption, or calcified canals. Teeth that develop iatrogenic complications during treatment (such as perforation, instrument fracture, or inability to complete the treatment). Teeth with complex anatomy (such as taurodontism, severe curvature, or elongated roots). Teeth requiring multi-session treatment due to continuous exudate from the canal or hemorrhage. Patients with temporomandibular joint (TMJ) disorders.

Design outcomes

Primary

MeasureTime frame
Postoperative pain intensity. Timepoint: At before and 6, 24, 48, and 72 hours post-treatment. Method of measurement: Visual Analog Scale (VAS, 0-10).

Secondary

MeasureTime frame
Post-treatment analgesic consumption. Timepoint: 6, 24, 48, and 72 hours after treatment. Method of measurement: Recording whether an analgesic was used or not at each time point, based on patient self-report.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAida Tavakoli roodi

Birjand University of Medical Sciences

aida_tavakkoli_1376@yahoo.com+98 56 3239 5000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026