The effect of the drug C-choline in improving the condition of patients with traumatic brain injury

Effect of Citicoline on the Cognitive Status and Functional Prognosis of Patients with Traumatic Brain Injury

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20251105067890N1

Enrollment

Registered

2025-11-24

Start date

2025-11-22

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Traumatic Brain Injury. Diffuse traumatic brain injury

Interventions

Intervention 1: Intervention group: Patients are included who receive citicoline (CDP-Choline) tablets. Each tablet contains 500 mg of citicoline and the dosage is twice a day (every 12 hours). The du

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: -Mild and moderate blunt brain injury Age 18-70 years Stable hemodynamics Non-sensitivity to ct-choline No severe chest, heart, or organ injury that would require surgery No history of brain injury

Exclusion criteria

Exclusion criteria: Pregnant or planning to become pregnant or breastfeeding women Underlying disease that may affect prognosis (heart, liver, kidney problems, malignancy) Taking acetylcholinesterase inhibitors Patients with a history of severe depression and cognitive impairment and hospitalization for this reason Surgery in the first 24 hours of trauma Cardiac resuscitation Patient dissatisfaction

Design outcomes

Primary

Measure	Time frame
Improving cognitive disorders. Timepoint: 3th day, 30th day, 90th day. Method of measurement: Mini-Mental State Examination (MMSE) questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Mamaghaniyan

Tabriz University of Medical Sciences

Dr.mamaghaniyan@gmail.com+98 41 3479 7797

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026