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Assessing the efficacy and safety of cold atmospheric plasma in combination with neoadjuvant chemotherapy for reducing tumor size in breast cancer patients

:Assessing the efficacy and safety of cold atmospheric plasma in combination with neoadjuvant chemotherapy for reducing tumor size in breast cancer patients: a clinical trial

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20251105067884N1
Enrollment
60
Registered
2025-11-11
Start date
2025-12-10
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

The effect of cold atmospheric plasma on invasive ductal tumors of the breast.. breast cancer/neoadjuvant therapy/cold atmospheric plasma/

Interventions

Intervention group: cold atmospheric plasma.

Sponsors

Iran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
35 Years to 70 Years

Inclusion criteria

Inclusion criteria: patient with breast cancer(IDC) Be a candidate for neoadjuvant therapy Have a measurable mass in breast Between 35 and 70 years old

Exclusion criteria

Exclusion criteria: The patient cannot tolerate preoperative chemotherapy for medical reasons. The patient is unwilling to participate in the study. The patient's tumor is not a measurable mass and is only microcalcifications. A patient who does not consent to preoperative chemotherapy

Design outcomes

Primary

MeasureTime frame
Reducing tumor size by injecting cold atmospheric plasma into it. Timepoint: One month after the plasma is injected into the tumor, a re-measurement is performed, and three months after the start of chemotherapy, surgery, and final pathology are determined. Method of measurement: sonography.

Secondary

MeasureTime frame
Investigating the effect of plasma on final pathology results, such as the extent of tumor invasion into blood vessels and nerves. Timepoint: Measurement of tumor size before plasma injection and one month after injection. Method of measurement: sonography.

Countries

Iran (Islamic Republic of)

Contacts

Public Contactsoheila sayad

Iranshahr University of Medical Sciences

sayad.soheila@yahoo.com+98 912 378 7312

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026