Elderly.
Conditions
Interventions
Intervention 1: Control group: The older adults in this group do not perform any specific physical activity and continue their usual daily activities. This group is used for comparison of biological a
Sponsors
Kerman University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: Age 60 to 75 years Female Relative general health and ability to perform light to moderate physical activity as approved by a physician Written informed consent to participate in the study Ability to regularly attend training sessions and conduct pre- and post-intervention tests Normal or mildly impaired cognitive level based on cognitive tests such as MMSE with a minimum score of 24 out of 30
Exclusion criteria
Exclusion criteria: Severe cardiovascular disease such as stage 3 or 4 heart failure uncontrolled arrhythmia or unstable angina History of heart attack or stroke in the past six months Presence of advanced chronic diseases such as end-stage renal failure, severe obstructive pulmonary disease, or active cancer Having severe neurocognitive disorders, such as advanced Alzheimer's or severe dementia, or untreated major depression Regular use of steroidal or nonsteroidal anti-inflammatory drugs, potent antioxidants, or anti-aging supplements in the past three months Participating in a regular strength or aerobic exercise program in the past six months Having musculoskeletal conditions or chronic pain that prevents resistance training Having uncontrolled diabetes or high blood pressure greater than 160 over 100 mmHg Inability to regularly participate in training sessions or conduct laboratory and cognitive assessments Participation in regular exercise or resistance training programs in the past six months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Interleukin-10. Timepoint: 24 hours before the start of the exercise protocol and 24 hours after the completion of the exercise protocol. Method of measurement: The level of interleukin-10 will be measured using the enzyme-linked immunosorbent assay (ELISA) method according to the instructions of the commercial kits. The results will be expressed as pg/mg of protein.;Tumor necrosis factor-alpha. Timepoint: 24 hours before the start of the exercise protocol and 24 hours after the completion of the exercise protocol. Method of measurement: The level of tumor necrosis factor-alpha will be determined using the enzyme-linked immunosorbent assay (ELISA) method according to the instructions of the commercial kits. The results will be reported as pg/mg of protein.;Malondialdehyde. Timepoint: 24 hours before the start of the exercise protocol and 24 hours after the completion of the exercise protocol. Method of measurement: Malondialdehyde measurement is performed using the thiobarbituric acid (TBA) spectrophotometric method (TBARS). In this method, MDA reacts with thiobarbituric acid to form a colored complex, whose absorbance at a specific wavelength reflects the level of lipid peroxidation.;Superoxide dismutase. Timepoint: 24 hours before the start of the exercise protocol and 24 hours after the completion of the exercise protocol. Method of measurement: Superoxide dismutase (SOD) is measured using a colorimetric method, in which the enzyme inhibits the formation of a colored formazan product from superoxide radicals, and the decrease in color intensity is proportional to SOD activity.;Glutathione peroxidase. Timepoint: 24 hours before the start of the exercise protocol and 24 hours after the completion of the exercise protocol. Method of measurement: Glutathione peroxidase (GPx) is measured using a colorimetric method, in which the enzyme reduces peroxides and prevents the formation of a colored product, and the decrease in color intensity is proportional to GPx activity | — |
Secondary
| Measure | Time frame |
|---|---|
| Weight. Timepoint: 24 hours before the start of the exercise protocol and 24 hours after the end of the exercise protocol. Method of measurement: Scale.;Body Mass Index. Timepoint: 24 hours before the start of the exercise protocol and 24 hours after the end of the exercise protocol. Method of measurement: A person’s weight in kilograms is divided by the square of their height in meters.;Blood pressure. Timepoint: 24 hours before the start of the exercise protocol and 24 hours after the end of the exercise protocol. Method of measurement: Blood pressure is measured using a sphygmomanometer, with the cuff inflated on the arm and the systolic and diastolic pressures determined by listening to or detecting arterial sounds.;Exercise adherence. Timepoint: Throughout the duration of the study. Method of measurement: Exercise adherence is measured through attendance records, self-reported exercise logs or questionnaires, and wearable devices such as smartwatches or accelerometers.;Quality of life. Timepoint: Before the start of the study and after the completion of the study. Method of measurement: Completion of the questionnaire by the participants.;Psychological indicators. Timepoint: Before the start of the study and after the completion of the study. Method of measurement: Completion of the questionnaire by the participants. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactKayvan Khoramipour
Miguel De Cervantes European University
Outcome results
None listed