menopausal genitourinary syndrome.
Conditions
Interventions
Intervention 1: Intervention group: Patients in this group use conjugated estrogen vaginal ointment (0.625 mg) for two months (every night in the first month, twice a week in the second month). Interv
Sponsors
Kurdistan University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
45 Years to 65 Years
Inclusion criteria
Inclusion criteria: Aged 45–65 years and sexually active Definitive diagnosis of genitourinary syndrome of menopause (GSM) based on clinical examination by a gynecologist and the standard Vaginal Health Index (VHI) checklist; patients with a score below 15 are eligible for the study At least one year since the last menstrual period Full informed consent to participate in the study No severe hormonal disorders No use of hormone therapy in the past 6 months Patients with contraindications to estrogen use (especially estrogen receptor–positive breast cancer, ovarian cancer, endometrial cancer, active thrombosis or history of thromboembolism, recent stroke or myocardial infarction, uncontrolled hypertension, advanced diabetes, or smoking) will be assigned to the platelet-rich plasma group
Exclusion criteria
Exclusion criteria: presence of inflammatory vaginal diseases Use of drugs affecting the reproductive system Presence of active genital infections Pregnancy and breastfeeding History of gynecological surgeries Use of corticosteroids
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The mean Vaginal Health Index score based on vaginal pH status, assessment of epithelial integrity, vaginal moisture, vaginal elasticity, and the condition of vaginal discharge. Timepoint: Before the intervention, and at one month and three months after the intervention. Method of measurement: Vaginal Health Index (VHI) scoring checklist.;Average score of women's sexual performance. Timepoint: Before the intervention, one month and three months after the intervention. Method of measurement: FSFI questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactLaleh Darvishi
Kurdistan University of Medical Sciences
Outcome results
None listed