Major Depressive Disorder. Major depressive disorder, single episode
Conditions
Interventions
Intervention 1: Intervention group: This group is prescribed two drugs, fluoxetine and dextromethorphan. Fluoxetine is administered in the form of capsules at a dose of 10 mg per day, starting with th
Sponsors
Gorgan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Age between 18 and 65 years diagnosis of major depressive disorder according to DSM-5-TR informed consent to enter the study
Exclusion criteria
Exclusion criteria: Pregnancy and breastfeeding uncontrolled suicidal thoughts psychosis history of psychiatric illness or comorbid disorder such as bipolar disorder, schizophrenia, alcohol and substance use disorder, personality disorder ECT performed in the past two months uncontrolled medical illness such as thyroid disorders, cardiovascular disease, diabetes, autoimmune disease, active infection, neurological disorders (epilepsy, stroke, dementia), hematological, hepatic, renal diseases and cancer history of serotonin syndrome in the patient concomitant use of serotonergic drugs (triptans, tramadol, etc.), ... recent depressive episode more than one year
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression score on the Hamilton Depression Rating Scale. Timepoint: Before the start of the study, 2, 4 and 8 weeks after the start of the study. Method of measurement: Hamilton Depression Rating Scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Response Rate: A reduction of more than 50% in the Hamilton Rating Scale is considered a response. Timepoint: Before the start of the study, 2, 4 and 8 weeks after the start of the study. Method of measurement: Hamilton Depression Rating Scale.;Remission rate: A reduction in the Hamilton Depression Rating scale to a number less than or equal to 7 is considered remission. Timepoint: Before the start of the study, 2, 4 and 8 weeks after the start of the study. Method of measurement: Hamilton Depression Rating Scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohammad Safi
Gorgan University of Medical Sciences
Outcome results
None listed