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Comparing the Effectiveness of Cognitive-Behavioral Therapy and Mindfulness-Based Stress Reduction in people with Mild Cognitive Impairments

Comparing the Effectiveness of Cognitive-Behavioral Therapy and Mindfulness-Based Stress Reduction on Quality of Life, Perceived Stress, Attention and Working Memory in Individuals with Mild Cognitive Impairments.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20251024067740N1
Enrollment
45
Registered
2025-11-04
Start date
2025-11-08
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild Cognitive Impairment. Mild cognitive impairment, so stated

Interventions

Intervention 1: Intervention group:Cognitive-Behavioral Therapy, Cognitive Behavioral Therapy (CBT), based on the classical cognitive-behavioral approach, will be conducted with the aim of improving t

Sponsors

Islamic Azad University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 80 Years

Inclusion criteria

Inclusion criteria: Receiving a confirmed diagnosis of Mild Cognitive Impairment (MCI) by a neurology specialist. Being between 60 and 80 years of age. Fluency in Persian language and having at least 8 years of formal education. The participant’s ability to attend treatment sessions as scheduled according to the therapeutic protocols and to regularly perform the exercises related to each intervention. The ability to write and fully complete the questions of self-report instruments and computer-based tools across the three stages of implementation.

Exclusion criteria

Exclusion criteria: A confirmed diagnosis of any type of progressive dementia. Having progressive neurological disorders, or a diagnosed cognitive impairment resulting from conditions such as COVID-19 infection, brain injury, stroke, multiple sclerosis (MS), Parkinson’s disease, or other similar causes. Absence from more than four sessions in any of the intervention programs. Exacerbation of symptoms, hospitalization, or undergoing anesthesia and surgery during the implementation of the protocols. Presence of severe visual or hearing impairments, history of stroke, transient ischemic attack (TIA), or head injury with a history of loss of consciousness. History of internal medical conditions such as uncontrolled diabetes, uncontrolled hypertension, uncontrolled hyperlipidemia, obstructive sleep apnea, or a history of HIV infection. Presence of major neurological or psychiatric disorders, including stroke, epilepsy, seizures, Parkinson’s disease, multiple sclerosis (MS), brain injuries, diagnosed schizophrenia, adult attention-deficit/hyperactivity disorder (ADHD), or any condition requiring frequent hospital visits or hospitalizations. Dependence on or abuse of substances or specific medications.

Design outcomes

Primary

MeasureTime frame
Quality of Life. Timepoint: Before the intervention – Immediately after the intervention – Three-month follow-up after the intervention. Method of measurement: world health organization- quality of life questionnaire (WHOQOL-100).;Perceived Stress. Timepoint: Before the intervention – Immediately after the intervention – Three-month follow-up after the intervention. Method of measurement: percieved stress scale-14 (PSS-14).;Attention. Timepoint: Before the intervention – Immediately after the intervention – Three-month follow-up after the intervention. Method of measurement: Cambridge Neuropsychological Test Automated Battery (CANTAB) will be used in the subtests of Rapid Visual Information Processing (RVP) and Match to Sample Visual Search (MTS).;Working Memory. Timepoint: Before the intervention – Immediately after the intervention – Three-month follow-up after the intervention. Method of measurement: Cambridge Neuropsychological Test Automated Battery (CANTAB) in the Spatial Working Memory (SWM) subtest.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAnahita Tarki

Islamic Azad University

anahitatarki2013@gmail.com+98 21 2670 0944

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026