Atrial Fibrillation After Coronary Artery Bypass Grafting. ???? ??????????? ?????? ?? ??? ????? 30 ?????
Conditions
Interventions
Intervention 1: Intervention group: Bempedoic acid tablets 180 mg, once daily from 5-7 days before surgery to 3 days after surgery. Intervention 2: Control group: placebo once daily from 5-7 days befo
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients over 18 years of age Elective isolated CABG candidate Patients who had been on a moderate-intensity statin (equivalent to atorvastatin at least 20 mg) for at least one month Patients who has LDL above 70 mg/dl Consented to participate in this study
Exclusion criteria
Exclusion criteria: GFR less than 30ml/min or requiring dialysis Liver failure patients with Child-Pugh C Known history of gout or treated with allopurinol Pregnancy or suspected pregnancy Breastfeeding Permanent pacemaker other than epicardial pacemaker Presence or history of AF rhythm at baseline Increased LA size (above 4 cm or LA volume index > 34 mL/m²) History of any cardiac surgery in the last 6 months Under treatment or history of receiving class I, III antiarrhythmic drugs Known history of hyperthyroidism or history of treatment with hyperthyroid drugs or TSH less than 0.1 mU/L Participation in other interventional clinical studies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AF rhythm recorded on a Holter monitor for more than 30 seconds. Timepoint: From the second day after surgery until the end of the fourth day after surgery. Method of measurement: Holter monitoring. | — |
Secondary
| Measure | Time frame |
|---|---|
| Occurrence of other types of arrhythmia. Timepoint: From the second day after surgery until the end of the fourth day after surgery. Method of measurement: Holter monitoring.;Length of hospital stay. Timepoint: From the time of CABG until discharge from the hospital. Method of measurement: Patient file.;Length of stay in intensive care units. Timepoint: From the time of CABG until the critical condition is resolved and discharge from the intensive care unit. Method of measurement: Patient file.;C-Reactive Protein (CRP). Timepoint: Baseline and third day after surgery. Method of measurement: lab test.;NLR (Ratio of neutrophil percentage to lymphocyte percentage). Timepoint: Baseline and third day after surgery. Method of measurement: lab test.;PLR (Ratio of Platelet percentage to lymphocyte percentage). Timepoint: Baseline and third day after surgery. Method of measurement: lab test.;MLR (Ratio of monocyte percentage to lymphocyte percentage). Timepoint: Baseline and third day after surgery. Method of measurement: lab test.;Hospital mortality. Timepoint: From the time of surgery until death occurs. Method of measurement: patient file. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactKeyhan Mohammadi
Tehran University of Medical Sciences
Outcome results
None listed