The effect of morphine before and during anesthesia on hemodynamics

Investigating comparison of Hemodynamic Changes Induced by Morphine Administration Before and During Anesthesia Induction in Laparoscopic Cholecystectomy: A Two way-Blind Randomized Clinical Trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20251021067708N1

Enrollment

Registered

2025-10-22

Start date

2025-11-22

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cholelithiasis. Calculus of gallbladder without cholecystitis

Interventions

Intervention 1: Intervention group: 0.1 mg/kg of morphine intravenously 20 minutes before the onset of anesthesia. Intervention 2: Intervention group: During induction, 0.1 mg/kg of morphine intraveno

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Candidate for elective laparoscopic cholecystectomy Consent to participate in the study

Exclusion criteria

Exclusion criteria: The patient is a candidate for emergency surgery.

Design outcomes

Primary

Measure	Time frame
Systolic Blood Pressure. Timepoint: 20 minutes and immediately before induction, 5 and 30 minutes after induction of anesthesia, after extubation, and after entering recovery. Method of measurement: Using Saadat Company's B9 vital signs monitor.;Diastolic Blood Pressure. Timepoint: 20 minutes and immediately before induction, 5 and 30 minutes after induction of anesthesia, after extubation, and after entering recovery. Method of measurement: Using Saadat Company's B9 vital signs monitor.;Heart Rate. Timepoint: 20 minutes and immediately before induction, 5 and 30 minutes after induction of anesthesia, after extubation, and after entering recovery. Method of measurement: Using Saadat Company's B9 vital signs monitor.;Mean Arterial Pressure. Timepoint: 20 minutes and immediately before induction, 5 and 30 minutes after induction of anesthesia, after extubation, and after entering recovery. Method of measurement: Using Saadat Company's B9 vital signs monitor.	—

Measure

Time frame

Systolic Blood Pressure. Timepoint: 20 minutes and immediately before induction, 5 and 30 minutes after induction of anesthesia, after extubation, and after entering recovery. Method of measurement: Using Saadat Company's B9 vital signs monitor.;Diastolic Blood Pressure. Timepoint: 20 minutes and immediately before induction, 5 and 30 minutes after induction of anesthesia, after extubation, and after entering recovery. Method of measurement: Using Saadat Company's B9 vital signs monitor.;Heart Rate. Timepoint: 20 minutes and immediately before induction, 5 and 30 minutes after induction of anesthesia, after extubation, and after entering recovery. Method of measurement: Using Saadat Company's B9 vital signs monitor.;Mean Arterial Pressure. Timepoint: 20 minutes and immediately before induction, 5 and 30 minutes after induction of anesthesia, after extubation, and after entering recovery. Method of measurement: Using Saadat Company's B9 vital signs monitor.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactZeinab Alizadeh

Yasouj University of Medical Sciences

alizadeh.md6010@gmail.com+98 74 3323 5153

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026