The effect of probiotics on the return of bowel function

The effect of probiotics on the return of bowel function and length of hospital stay in patients after cesarean section: A randomized clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20251021067706N1

Enrollment

150

Registered

2026-02-16

Start date

2026-03-02

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative ileus, characterized by delayed recovery of bowel function, is a common complication following cesarean section. It can lead to patient discomfort and prolonged hospital stay. This study investigates the effect of probiotic supplementation on bowel function recovery and length of hospitalization after cesarean delivery.. Other postprocedural complications and disorders of digestive system

Interventions

Intervention 1: Intervention group: The intervention group, in addition to routine care, will receive Bio Flora probiotic capsules containing the bacterial strains Lactobacillus acidophilus, Bifidobac

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Informed consent to participate in the study Nulliparous or multiparous women aged 18 to 40 Candidate for cesarean section with spinal anesthesia Body mass index (BMI) less than 35 No chronic or pregnancy-related disease No history of intestinal surgery No history of constipation, pancreatitis or peritonitis, hypothyroidism, muscle and nerve disorders, or ileus before surgery

Exclusion criteria

Exclusion criteria: Hysterectomy with cesarean section Postpartum hemorrhage Postoperative fluid and electrolyte disturbances preoperative and postoperative complications Patient intolerance Unwillingness to continue participating in the study Failure to meet the conditions for the patient to become PO within the first 2 hours Emergency cesarean sections will be excluded from the study population due to their unpredictability.

Design outcomes

Primary

Measure	Time frame
Surgical duration. Timepoint: will be recorded after surgery. Method of measurement: Measured in hours.;Symptoms of ileus after surgery. Timepoint: The participants will be assessed at 8,12 and 24 hours postoperatively . Bowel sounds will be auscultated by a physician, and sign of ileus , including abdominal distension and vomiting will be recorded. Method of measurement: Using the questionnaire and clinical examination findings.;Intra-abdominal adhesion. Timepoint: will be recorded after surgery. Method of measurement: Using the questionnaire and findings from the operative report.;Hospitalization duration. Timepoint: Assessments will be conducted at 8,12,24 and 48 hours after surgery and subsequently until discharge if the patient remains hospitalized. Method of measurement: Measured in days.;Amount of intravenous fluids received. Timepoint: Assessments will be conducted at 8,12 and 24 hours after surgery. Method of measurement: in liters.;Need for enemas. Timepoint: Assessments will be conducted at 8,12 and 24 hours after surgery. Method of measurement: Using the questionnaire and findings from the operative report.;First peristalsis. Timepoint: Assessments will be conducted at 8,12 and 24 hours after surgery. Method of measurement: Using the questionnaire and findings from the operative report.;First hunger sensation. Timepoint: Assessments will be conducted at 8,12 and 24 hours after surgery. Method of measurement: Using the questionnaire.;First time of gas passing. Timepoint: Assessments will be conducted at 8,12 and 24 hours after surgery. Method of measurement: Using the questionnaire.;First time of defecation. Timepoint: Assessments will be conducted at 8,12 and 24 hours after surgery. Method of measurement: Using the questionnaire.	—

Measure

Time frame

Surgical duration. Timepoint: will be recorded after surgery. Method of measurement: Measured in hours.;Symptoms of ileus after surgery. Timepoint: The participants will be assessed at 8,12 and 24 hours postoperatively . Bowel sounds will be auscultated by a physician, and sign of ileus , including abdominal distension and vomiting will be recorded. Method of measurement: Using the questionnaire and clinical examination findings.;Intra-abdominal adhesion. Timepoint: will be recorded after surgery. Method of measurement: Using the questionnaire and findings from the operative report.;Hospitalization duration. Timepoint: Assessments will be conducted at 8,12,24 and 48 hours after surgery and subsequently until discharge if the patient remains hospitalized. Method of measurement: Measured in days.;Amount of intravenous fluids received. Timepoint: Assessments will be conducted at 8,12 and 24 hours after surgery. Method of measurement: in liters.;Need for enemas. Timepoint: Assessments will be conducted at 8,12 and 24 hours after surgery. Method of measurement: Using the questionnaire and findings from the operative report.;First peristalsis. Timepoint: Assessments will be conducted at 8,12 and 24 hours after surgery. Method of measurement: Using the questionnaire and findings from the operative report.;First hunger sensation. Timepoint: Assessments will be conducted at 8,12 and 24 hours after surgery. Method of measurement: Using the questionnaire.;First time of gas passing. Timepoint: Assessments will be conducted at 8,12 and 24 hours after surgery. Method of measurement: Using the questionnaire.;First time of defecation. Timepoint: Assessments will be conducted at 8,12 and 24 hours after surgery. Method of measurement: Using the questionnaire.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactPegah Hasanshahi

Shahre-kord University of Medical Sciences

aurorapegahhh@gmail.com+98 71 3626 6788

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026