The Effect of Platelet-Rich Plasma (PRP) Injection on the Healing of Intra-Articular Ankle Fractures

Investigating the effects of platelet rich plasma injected intra-articularly on patients with intra-articular ankle fractures: Single blinded clinical trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20251020067701N1

Enrollment

Registered

2025-10-31

Start date

2025-10-30

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intra-articular ankle fracture.

Interventions

Intervention group: A senior orthopedic assistant will prepare the LR-PRP injections for the intervention group. For the first 2 mL of LR-PRP, 20 mL of whole blood will be drawn initially from the pat

however, to obtain 4 mL of LR-PRP, 40 mL of whole blood will be drawn instead of 20 mL. Subsequently, 4 mL of ACD-A will be added as an anticoagulant, and the sample will undergo the same two-step cen

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Absence of pregnancy and breastfeeding No vascular problems in the legs Not having rheumatoid arthritis No ankle arthritis Absence of ankle deformity Not suffering from mental disability Absence of psychiatric illnesses No previous surgery at the site of injury No bilateral ankle instability Absence of ankle bone lesions

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain score using the Visual Analog Scale (VAS) questionnaire. Timepoint: At baseline, and at 3 and 6 months after injection. Method of measurement: The Visual Analog Scale (VAS) questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHamidreza Adabifirouzjaee

Islamic Azad University

hamidrezaadabi25@gmail.com+98 23 3239 4465

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026