Comparison of the effect of infiltrative injection of ketorolac and articain on the success of inferior alveolar nerve block in mandibular molars with symptomatic irreversible pulpitis

Comparison of the effect of infiltrative injection of ketorolac and articain on the success of inferior alveolar nerve block in mandibular molars with symptomatic irreversible pulpitis a randomized double-blind clinial trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20251018067669N1

Enrollment

Registered

2025-12-10

Start date

2026-01-20

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

symptomatic irreversible pulpitis.

Interventions

Intervention 1: Intervention group: infiltrative injection of ketorolac and lidocaine. Intervention 2: Control group: infiltrative injection of articaine.

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: irreversible pulpitis mandibular molar healthy patient

Exclusion criteria

Exclusion criteria: History of any sensitivity or contraindication to nonsteroidal anti-inflammatory drugs or local anesthetics Pregnancy and breastfeeding Taking drugs that affect the central nervous system, such as alcohol or drugs Pain medication use in the past 24 hours Antidepressants or sedatives within the past four hours Cracked or broken teeth open apex Lack of soft tissue anesthesia after block injection Pain in more than one tooth Presence of an apical lesion with a diameter of more than one millimeter Liver or kidney problems active asthma Pulp necrosis

Design outcomes

Primary

Measure	Time frame
Increase the inferior alveolar nerve block. Timepoint: 1 hour. Method of measurement: visual analogue scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad marvi sabagh

Tehran University of Medical Sciences

mohammadmarvi.68@gmail.com+98 912 394 9265

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026