Comparative Analgesic Efficacy of Gabapentin and Pregabalin in Elective Tendon and Nerve Repair surgeries of the Hand

Comparative Analgesic Efficacy of Gabapentin and Pregabalin in Elective Tendon and Nerve Repair surgeries of the Hand: A Randomized Clinical Trial at Shahid Bahonar Hospital, Kerman (2025)

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20251015067640N1

Enrollment

Registered

2025-11-15

Start date

2025-03-25

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Analgesic effect after elective tendon and nerve repair surgery.

Interventions

Intervention 1: Intervention Group 1 (Gabapentin Group):Patients in this group will receive 600 mg of oral Gabapentin one hour before surgery as a prophylactic measure to prevent postoperative pain. G

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age between 18 and 65 years American Society of Anesthesiologists (ASA) Physical Status I or II Candidates foe elective tendon or nerve repair surgery of the hand Providing written informed consent to participate in the study

Exclusion criteria

Exclusion criteria: Known hypersensitivity or allergy to Gabapentin or Pregabalin Severe hepatic or renal impairment Chronic use of analgesic or antiepileptic drugs, including Opioids, non-steroidal anti-inflammatory drugs (NSAIDs), Acetaminophen, Phenytoin, Carbamazepine, Valproate, Gabapentin, and Pregabalin, within the past two weeks. Pregnancy or lactation History of substance abuse

Design outcomes

Primary

Measure	Time frame
Postoperative pain intensity at rest. Timepoint: Pain intensity at rest will be measured at 2, 6, 12, 24, and 48 hours after surgery. Method of measurement: Pain intensity at rest will be assessed using the Visual Analogue Scale (VAS; 0–10), where 0 indicates no pain and 10 represents the worst imaginable pain. Assessments will be performed by a trained nurse blinded to group allocation.;Postoperative pain intensity during movement. Timepoint: Pain intensity during movement will be measured at 2, 6, 12, 24, and 48 hours after surgery. Method of measurement: Pain intensity during movement will be assessed using the Visual Analogue Scale (VAS; 0–10), where 0 indicates no pain and 10 represents the worst imaginable pain. Measurements will be obtained by a trained nurse blinded to treatment assignment.	—

Measure

Time frame

Postoperative pain intensity at rest. Timepoint: Pain intensity at rest will be measured at 2, 6, 12, 24, and 48 hours after surgery. Method of measurement: Pain intensity at rest will be assessed using the Visual Analogue Scale (VAS; 0–10), where 0 indicates no pain and 10 represents the worst imaginable pain. Assessments will be performed by a trained nurse blinded to group allocation.;Postoperative pain intensity during movement. Timepoint: Pain intensity during movement will be measured at 2, 6, 12, 24, and 48 hours after surgery. Method of measurement: Pain intensity during movement will be assessed using the Visual Analogue Scale (VAS; 0–10), where 0 indicates no pain and 10 represents the worst imaginable pain. Measurements will be obtained by a trained nurse blinded to treatment assignment.

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Secondary

Measure	Time frame
Total postoperative analgesic consumption within 48 hours. Timepoint: Total analgesic consumption will be recorded during the first 48 hours after surgery. Method of measurement: The total amount of analgesics (paracetamol, tramadol, morphine) administered will be extracted from medical records and recorded in milligrams by a trained nurse.;Incidence of drug-related adverse effects within 48 hours. Timepoint: Adverse effects will be assessed at 24 and 48 hours after surgery. Method of measurement: Symptoms such as dizziness, nausea, somnolence, blurred vision, and ataxia will be documented through direct observation and patient questioning by a trained nurse.	—

Measure

Time frame

Total postoperative analgesic consumption within 48 hours. Timepoint: Total analgesic consumption will be recorded during the first 48 hours after surgery. Method of measurement: The total amount of analgesics (paracetamol, tramadol, morphine) administered will be extracted from medical records and recorded in milligrams by a trained nurse.;Incidence of drug-related adverse effects within 48 hours. Timepoint: Adverse effects will be assessed at 24 and 48 hours after surgery. Method of measurement: Symptoms such as dizziness, nausea, somnolence, blurred vision, and ataxia will be documented through direct observation and patient questioning by a trained nurse.

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Countries

United States of America

Contacts

Public ContactJaber Darijani

Kerman University of Medical Sciences

j_darijani@kmu.ac.ir983432513975

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026