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Comparison of intravenous ibuprofen and ketorolac for pain relief after abdominal surgery

Investigating the effect of intravenous ibuprofen versus ketorolac for pain control after abdominal surgery

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20251014067631N1
Enrollment
24
Registered
2025-11-08
Start date
2025-11-11
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain control after abdominal surgery. Pain, unspecified

Interventions

Intervention 1: Intervention group: Participants in the intervention group will receive intravenous ibuprofen 800 mg (2 mL of 400 mg/mL solution) administered one hour before surgery as a single dose.

Sponsors

Tehran Azad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Age between 18–65 years Elective abdominal surgery ASA class I or II Written informed consent to participate No history of drug abuse, alcohol, or psychiatric medications

Exclusion criteria

Exclusion criteria: Decreased level of consciousness Hemodynamic instability Abnormal intraoperative bleeding Surgery duration longer than 4 hours

Design outcomes

Primary

MeasureTime frame
Postoperative pain score measured using the Visual Analogue Scale (VAS). Timepoint: 0, 6, 12, and 24 hours postoperatively. Method of measurement: Visual Analogue Scale (VAS), 0 = no pain, 10 = worst imaginable pain.

Secondary

MeasureTime frame
Total dose of rescue analgesic (pethidine, mg/kg) administered within 24 hours post-surgery. Timepoint: Cumulative over the first 24 postoperative hours. Method of measurement: Total administered pethidine dose recorded from medical chart.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMatin Feizi

Tehran Islamic Azad University of Medical Sciences

matinfeizi7@gmail.com00999395282008

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026