The effect of sacubitril/valsartan on blood pressure control and weight gain between hemodialysis sessions

The effect of sacubitril/valsartan on blood pressure control and weight gain between hemodialysis sessions in patients with end-stage renal failure: A randomized controlled clinical trial study

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20251014067624N2

Enrollment

100

Registered

2026-05-17

Start date

2026-06-22

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

End stage renal disease. End stage renal disease

Interventions

Intervention 1: Intervention group: Receiving sacubitril/valsartan 24/26 mg every 12 hours in addition to standard antihypertensive therapy for six months. Intervention 2: Control group: Receiving val

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: Willingness to participate in the study Having ESRD Regular hemodialysis 2–3 times a week Urine output of more than 500 cc in 24 hours

Exclusion criteria

Exclusion criteria: Blood pressure less than 90/50 mmHg Serum potassium above 5.5 mEq/L History of angioedema or contraindication to ARB/ACEI use The need for a fundamental change in the medication regimen that eliminates the possibility of treatment failure Unwillingness to continue cooperation

Design outcomes

Primary

Measure	Time frame
Measuring blood pressure levels. Timepoint: Before and after each hemodialysis session over a six-month period. Method of measurement: Mercury sphygmomanometer.;Interdialytic weight gain (IDWG). Timepoint: Before and after each hemodialysis session over a six-month period. Method of measurement: Digital body scale.;Checking physical condition and chronic fatigue level. Timepoint: Before and after each hemodialysis session over a six-month period. Method of measurement: Valid and standardized fatigue questionnaire (Fatigue Severity Scale – FSS).	—

Measure

Time frame

Measuring blood pressure levels. Timepoint: Before and after each hemodialysis session over a six-month period. Method of measurement: Mercury sphygmomanometer.;Interdialytic weight gain (IDWG). Timepoint: Before and after each hemodialysis session over a six-month period. Method of measurement: Digital body scale.;Checking physical condition and chronic fatigue level. Timepoint: Before and after each hemodialysis session over a six-month period. Method of measurement: Valid and standardized fatigue questionnaire (Fatigue Severity Scale – FSS).

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarahnoosh Farnood

Tabriz University of Medical Sciences

farnoodkidney@gmail.com+98 914 307 9418

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026