Effect of curcumin supplement on levels of uremic toxins in dialysis patients

Effect of curcumin supplement on serum levels of indoxyl sulfate and p-Cresyl sulfate in hemodialysis patients

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20251014067619N2

Enrollment

Registered

2025-12-01

Start date

2025-12-22

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Kidney Disease. Chronic kidney disease (CKD)

Interventions

Intervention 1: Intervention group: Curcumin supplement (Dineh Company, 50 mg)

one supplement each 8 hours (3 supplement doses in 24 hours) for 12 weeks. Intervention 2: Control group: Maltodextrin-containing gelatin capsule, one capsule each 8 hours for 12 weeks.

Eligibility

Sex/Gender

All

Age

25 Years to 60 Years

Inclusion criteria

Inclusion criteria: On dialysis for 6 months or more

Exclusion criteria

Exclusion criteria: BMI above 30 History of malignancy Use of corticosteroids and immunosuppressive medicines Scheduled use of NSAIDs

Design outcomes

Primary

Measure	Time frame
Serum levels of Indoxyl sulfate. Timepoint: 12 weeks after supplement consumption. Method of measurement: Colorimetric assay.	—

Secondary

Measure	Time frame
Serum levels of p-cresyl sulfate. Timepoint: 12 weeks after supplement consumption. Method of measurement: Colorimetric assay.;Serum levels of highly sensitive CRP (hs-CRP). Timepoint: 12 weeks after supplement consumption. Method of measurement: ELISA.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAlireza Mardomi

Tabriz University of Medical Sciences

mardomia@tbzmed.ac.ir098413334665

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026