Premature ovarian insufficiency. Female infertility
Conditions
Interventions
Intervention group: Exosome-administrated patients.
Sponsors
PerciaVista
Eligibility
Sex/Gender
Female
Age
No minimum to 40 Years
Inclusion criteria
Inclusion criteria: Post-menarche female less than 40 years old Primary or secondary amenorrhea at least for 3-6 months Diagnosis of premature ovarian failure or insufficiency: At least two menopausal FSH levels (= 20 IU/L) Clinical diagnosis of Premature Ovarian Failure AMH10 million sperms/ml).
Exclusion criteria
Exclusion criteria: Abnormal physical conditions Diagnosed with autoimmune diseases Patients with congenital ovarian malformations Patients with severe endometriosis Patients with pregnancy contraindications Diagnosed with thyroid dysfunction Past history of malignancy/chemotherapy/radiotherapy Infectious diseases: HIV+, hepatitis B+, C+ Diagnosed with abnormal karyotype Previous surgical management of ovarian pathology Enrollment in other trials in the last 3 months Presence of adnexal masses or tenderness indicating the need for further evaluation Major mental health disorder that precludes participation in the study Active substance abuse or dependence Current or recent (within the past 3 months) use of the following medications: Oral or systemic corticosteroids, Hormones (estrogen, progestins, oral contraceptives), Danazol, anticoagulants, Herbal or botanical supplements with possible hormonal effects Type I or Type II diabetes mellitus or if receiving anti-diabetic medications Hb <11 g/dL, platelets <150,000/mm3 Patient with bleeding diathesis Use of NSAIDs in the 10 days before procedure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improving ovarian follicular population. Timepoint: Periodic examinations for up to 12 months will be performed to check the repair of ovarian tissue in terms of follicular growth and development using ultrasound and changes in serum levels of sex hormones on a monthly basis. Method of measurement: Ultrasound images.;Regulating blood levels of sex hormones such as FSH, LH, E2, AMH. Timepoint: Periodic examinations for up to 12 months will be performed to check the repair of ovarian tissue in terms of follicular growth and development using ultrasound and changes in serum levels of sex hormones on a monthly basis. Method of measurement: Sex hormone level results. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMahdi Mahdipour
Tabriz University of Medical Sciences
Outcome results
None listed