Comparative Evaluation of Photobiomodulation Therapy Combined with Oral Bromelain (Anaheal) in the Management of pain

Comparative Evaluation of Photobiomodulation Therapy Combined with Oral Bromelain (Anaheal) in the Management of Myofascial Pain Dysfunction Syndrome (MPDS)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20251013067608N1

Enrollment

Registered

2025-12-11

Start date

2025-12-20

Completion date

Unknown

Last updated

2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myofascial Pain Dysfunction Syndrome (MPDS).

Interventions

Intervention 1: Intervention group: 1. Group receiving low-level laser therapy. Intervention 2: Intervention group: 2. Group receiving Anaheal capsules, 500 mg dose, once a day, for 10 days. Intervent

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Age 18 to 60 years Presence of masticatory muscle pain lasting at least 6 months Pain when touching the masticatory muscles Normal posterior occlusion

Exclusion criteria

Exclusion criteria: Presence of temporomandibular joint disorders of articular origin meeting research diagnostic criteria for TMD Systemic diseases including: cardiovascular, infectious, inflammatory diseases, epilepsy, head and neck tumors, or psychiatric diseases affecting the patient's clinical condition History of trauma to the jaw and face Having osteoarthritis or a herniated cervical disc Using removable dentures Severe malocclusion (e.g. overjet greater than 6 mm) Patients with "coagulation deficiency" or "risk of bleeding" problems

Design outcomes

Primary

Measure	Time frame
VAS (Visual Analog Scale): A numerical scale from 0 to 10 for the intensity of pain in the masticatory muscles (temporal, master, lateral trigoid and medial trigoid) in the resting and functional state bilaterally and examining the TMJ by touch 2. MMO (Maximum Mouth Opening): The greatest distance the mouth can be opened without pain is measured with a ruler. The normal range of this value is between 40 and 60 mm; values ??below 35 mm indicate limited movement. 3. Protrusion: Measurement of the displacement of the lower jaw forward relative to the upper teeth; the normal value is between 7 and 10 mm. 4. Lateral movements: The displacement of the jaw to the left and right from the midline is measured separately; the normal value is about 7 to 12 mm on each side. Timepoint: Two to three times a week. Method of measurement: Visual analog scale, digital caliper.	—

Measure

Time frame

VAS (Visual Analog Scale): A numerical scale from 0 to 10 for the intensity of pain in the masticatory muscles (temporal, master, lateral trigoid and medial trigoid) in the resting and functional state bilaterally and examining the TMJ by touch 2. MMO (Maximum Mouth Opening): The greatest distance the mouth can be opened without pain is measured with a ruler. The normal range of this value is between 40 and 60 mm; values ??below 35 mm indicate limited movement. 3. Protrusion: Measurement of the displacement of the lower jaw forward relative to the upper teeth; the normal value is between 7 and 10 mm. 4. Lateral movements: The displacement of the jaw to the left and right from the midline is measured separately; the normal value is about 7 to 12 mm on each side. Timepoint: Two to three times a week. Method of measurement: Visual analog scale, digital caliper.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Maryam Sadat Sadrzadeh Afshar

Artesh University of Medical Sciences

m_sadrzade@alumnus.tums.ac.ir+98 21 7787 5650

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026