Effect of local injection of vitamin B6 in carpal tunnel syndrome

Comparison of the effectiveness of local injection of vitamin B6 and steroid injection under ultrasound guidance on clinical and ultrasound findings of the median nerve in carpal tunnel syndrome (CTS)

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20251013067607N1

Enrollment

Registered

2026-02-15

Start date

2026-03-30

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nerve compression or entrapment of the median nerve in the wrist (carpal tunnel syndrome). Carpal tunnel syndrome

Interventions

Intervention 1: Intervention group: In 25 patients with mild or moderate carpal tunnel syndrome, a topical combination of vitamin B6 and lidocaine in the amount of 2 cc of the drug (including 1 cc of

Eligibility

Sex/Gender

All

Age

20 Years to 60 Years

Inclusion criteria

Inclusion criteria: Age of 20 to 60 years Final diagnosis of mild to moderate carpal tunnel syndrome (accurate diagnosis with nerve and muscle imaging) Patient's willingness to participate in a research study

Exclusion criteria

Exclusion criteria: Patients who do not cooperate with the necessary follow-up after the injection Severe hand dysfunction that requires surgical release of the median nerve History of steroid injection into the carpal tunnel and history of surgery Drug sensitivity to the drugs used in the plan Severe carpal tunnel syndrome Neuropathy, fracture, or burn in the affected limb

Design outcomes

Primary

Measure	Time frame
Pain in hand & wrist based on VAS scale. Timepoint: Clinical findings 3 weeks and 3 months after the second injection will also be recorded and compared with findings before the injection. Method of measurement: Researcher-made checklist. Pain intensity by Visual Analogue Scale (VAS).;Paresthesia and numbness in the limb according to the BCTQ questionnaire. Timepoint: Clinical findings 3 weeks and 3 months after the second injection will also be recorded and compared with findings before the injection. Method of measurement: Degree of paresthesia and numbness based on Boston Carpal Tunnel Questionnaire (BCTQ).;Weakness and disability due to compression of the median nerve. Timepoint: Clinical findings 3 weeks and 3 months after the second injection will also be recorded and compared with findings before the injection. Method of measurement: Degree of disability based on Boston Carpal Tunnel Questionnaire (BCTQ).;CSA (median nerve cross-sectional area) and longitudinal diameter of the nerve at the beginning (entrance) of the canal and the end (exit) of the carpal canal. Timepoint: Ultrasound findings will also be recorded 3 weeks and 3 months after the second injection and compared with the findings before the injection. Method of measurement: Measuring the dimensions of the median nerve using an ultrasound device.	—

Measure

Time frame

Pain in hand & wrist based on VAS scale. Timepoint: Clinical findings 3 weeks and 3 months after the second injection will also be recorded and compared with findings before the injection. Method of measurement: Researcher-made checklist. Pain intensity by Visual Analogue Scale (VAS).;Paresthesia and numbness in the limb according to the BCTQ questionnaire. Timepoint: Clinical findings 3 weeks and 3 months after the second injection will also be recorded and compared with findings before the injection. Method of measurement: Degree of paresthesia and numbness based on Boston Carpal Tunnel Questionnaire (BCTQ).;Weakness and disability due to compression of the median nerve. Timepoint: Clinical findings 3 weeks and 3 months after the second injection will also be recorded and compared with findings before the injection. Method of measurement: Degree of disability based on Boston Carpal Tunnel Questionnaire (BCTQ).;CSA (median nerve cross-sectional area) and longitudinal diameter of the nerve at the beginning (entrance) of the canal and the end (exit) of the carpal canal. Timepoint: Ultrasound findings will also be recorded 3 weeks and 3 months after the second injection and compared with the findings before the injection. Method of measurement: Measuring the dimensions of the median nerve using an ultrasound device.

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Secondary

Measure	Time frame
No. Timepoint: no. Method of measurement: no.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSomaye Zohali

Bagheiat-allah University of Medical Sciences

Somayehzohali@gmail.com+98 21 8805 0435

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026