Depression in Bipolar patients. Bipolar disorder, current episode depressed, severe, without psychotic features
Conditions
Interventions
Intervention 1: Intervention Group: Patients in the intervention group will receive, in addition to the standard pharmacological treatment they have been already receiving, a daily dose of 1800 mg to
Sponsors
Ahvaz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients diagnosed with bipolar depression according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria. A score greater than 8 on the Hamilton Depression Rating Scale. Patients hospitalized in the Psychiatry Ward of Golestan Hospital Patients in the age range of 18-65 years
Exclusion criteria
Exclusion criteria: The use of any other medication that has antidepressant effects, except for the study drug, or mood stabilizers or antipsychotics that have been initiated for the patient. The presence of comorbid psychiatric disorders such as schizoaffective disorder or other psychotic disorders like schizophrenia Acute substance, sedative, or alcohol dependence or abuse within the past 12 months (excluding nicotine), as defined by the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition criteria for substance dependence, or a positive urine drug test at the start of the study Sensitivity to N-acetylcysteine or to any of the components present in the placebo. Diagnosis of major depressive disorder (unipolar depression) based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. Diagnosis of a manic episode based on the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. Individuals with intellectual disabilities or other cognitive disorders Neurological disorders such as dementia, delirium, head trauma, or seizure disorders Pregnant women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depressive symptoms. Timepoint: At the beginning of study and 4th and 8th week of study. Method of measurement: Hamilton Depression Rating Scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Cognitive function. Timepoint: At the beginning of study and 4th and 8th week of study. Method of measurement: Montreal Cognitive Assessment. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactShahin Norouzi
Ahvaz University of Medical Sciences
Outcome results
None listed