Postoperative pain. Other acute postprocedural pain
Conditions
Interventions
Intervention 1: Intervention group: Patients receive a single oral dose of 400 milligrams of Carbamazepine two hours before the surgery. To ensure blinding, the medication is administered in identical
Sponsors
Kerman University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Candidates for elective hand surgery including tendon, nerve, or soft tissue repair Age between 18 and 65 years ASA physical status class I or II Predicted surgical duration between 45 and 120 minutes No known hypersensitivity to Carbamazepine or Sodium Valproate Providing written informed consent Ability to understand and respond to pain assessment questions
Exclusion criteria
Exclusion criteria: History of hypersensitivity or allergy to Carbamazepine, Sodium Valproate, or other anticonvulsants Severe hepatic dysfunction defined as ALT or AST more than 3 times the normal limit Severe renal dysfunction defined as serum creatinine above 2 mg per dL Chronic use of analgesics, anticonvulsants, or antidepressants within the past 2 weeks Pregnancy or breastfeeding History of substance abuse or alcohol addiction Known blood disorders such as severe anemia or coagulation disorders History of seizures or epilepsy Severe psychiatric disorders or significant mood changes Severe heart failure or serious arrhythmias Extensive hand surgeries with significant tissue loss or complex multi-structural procedures
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative pain intensity. Timepoint: Before the intervention (baseline), and 2, 6, 12, 24, and 48 hours after the surgery. Method of measurement: Visual Analogue Scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactJaber Darijani
Kerman University of Medical Sciences
Outcome results
None listed