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Efficacy of Treatment with 2% Tofacitinib Niosomal Lotion Compared to 0.01% Clobetasol Lotion

Comparative Study between Efficacy of Tofacitinib Niosomal 2% Lotion versus Clobetasol 0.01% Lotion in Alopecia Areata

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20251010067571N1
Enrollment
40
Registered
2025-10-18
Start date
2025-10-16
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alopecia areata. Alopecia areata

Interventions

Intervention 1: Intervention group: The first Group was Treated with 2% Tofacitinib Niosomal Lotion. Intervention 2: Intervention group: The second Group was Treated with 0.01% Clobetasol Lotion.

Sponsors

Kerman University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
4 Years to No maximum

Inclusion criteria

Inclusion criteria: Age Equal to or Greater Than Four Years Alopecia Areata Patchy Form (SALT = 25%) Not Using Other Hair Loss Treatments in the Past Three Months Ability and Willingness to Follow Instructions for Using Lotions Normal Tests Include: CBC, Creatinine, Liver Tests, Thyroid Tests, Anti-Thyroperoxidase and Thyroglobulin Antibodies, and FBS

Exclusion criteria

Exclusion criteria: History of Autoimmune Diseases and Use of Biological Therapies and Immunosuppressants Within the Past 6 Months Use of Topical Corticosteroids in the Past Month at the Site Pregnancy, Breastfeeding Phototherapy within the past 3 Months Thyroid Dysfunction Cytopenia (Leukocytes > 3 × 10^9, Lymphocytes > 0.8 × 10^9, Neutrophils < Lower Limit of Normal Range, Hemoglobin < 10 g/dl, Platelets < 100 × 10^9)

Design outcomes

Primary

MeasureTime frame
Hair Loss Treatment. Timepoint: 12 Weeks. Method of measurement: Measuring the Percentage of Hair Loss with SALT Score, Regrowth Rate.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBanafshe Farzadfard

Kerman University of Medical Sciences

banafshefrzd@gmail.com+98 34 3132 8328

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026