effect acellular dermal graft in small tympanic membrane perforations

Comparison of acellular dermal graft vs paper patch application in small tympanic membrane perforations

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT20251007067535N1

Enrollment

Registered

2025-10-20

Start date

2025-11-11

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

tympanic membrane perforations. perforation of ear drum:persistent post-traumaticpostinflammatory

Interventions

Intervention 1: Intervention group: Repair using acellular dermal graft. Intervention 2: Control group: Repair using paper patch.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The presence of a dry central hole in the tympanic membrane The hole remains for at least 3 months. No bone pathology or mastoid disease

Exclusion criteria

Exclusion criteria: Presence of granulation tissue at the perforation site Persistent ear discharge (persistent otorrhea) Severe dizziness Temporal bone fracture Tympanoplasty history Severe hearing loss

Design outcomes

Primary

Measure	Time frame
Repair of tympanic membrane perforation. Timepoint: One and three months after the intervention. Method of measurement: Undergoing otoscopy examination.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Shekari

Shahid Beheshti University of Medical Sciences

Maryam.shekari.0619@gmail.com+98 21 5541 9005

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026