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The Effect of Intraperitoneal Dexamethasone Combined with Bupivacaine plus a Pulmonary Maneuver on Common Complications Following Laparoscopic Cholecystectomy

Investigation of the Effect of Intraperitoneal Dexamethasone Combined with Bupivacaine along with Lung Recruitment Maneuver Positioning on Pain, Nausea and Vomiting after Laparoscopic Cholecystectomy

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20251007067533N1
Enrollment
80
Registered
2025-10-19
Start date
2025-10-22
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Postoperative Abdominal Pain After Laparoscopic Cholecystectomy. Condition 2: Postoperative Nausea and Vomiting after Laparoscopic Cholecystectomy. Condition 3: Postoperative Shoulder Pain After Laparoscopic Cholecystectomy.

Interventions

Intervention 1: Intervention group one: At the end of the surgery, before the removal of the cannulas and the closure of the incision sites in the abdomen, by changing the reverse Trendelenburg positi
then, by changing the position from Trendelenburg to the supine position, the Pulmonary Recruitment Maneuver for CO2 gas evacuation will be performed with 5 high-volume manual breaths unti

Sponsors

Mazandaran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients undergoing elective laparoscopic cholecystectomy who have provided written informed consent Aged 18 to 60 years American Society of Anesthesiologists (ASA) physical status classification of I or II Anticipated surgery duration of less than 2 hours No known history of hypersensitivity to dexamethasone, bupivacaine, or anesthetic agents Body Mass Index (BMI) < 40 kg/m²

Exclusion criteria

Exclusion criteria: Patients unwilling to participate or who decline to provide informed consent Presence of any contraindication to the pulmonary recruitment maneuver History of previous abdominal or shoulder surgery History of opioid use, alcohol consumption, and long-term use of steroidal and non-steroidal anti-inflammatory drugs History of chronic pain unrelated to gallbladder disease Pregnancy or lactation Presence of significant cardiovascular, pulmonary, renal, hepatic, neurological, or psychiatric diseases; diabetes mellitus; or inflammatory conditions of the shoulder

Design outcomes

Primary

MeasureTime frame
Abdominal Pain. Timepoint: At 2, 6, 12, 18, 24, and 48 hours postoperatively. Method of measurement: Visual Analog Scale.;Shoulder Pain. Timepoint: At 2, 6, 12, 18, 24, and 48 hours postoperatively. Method of measurement: Visual Analog Scale.;Postoperative Nausea and Vomiting. Timepoint: At 2, 6, 12, 18, 24, and 48 hours postoperatively. Method of measurement: Emesis Score.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMiad Haddadian

Mazandaran University of Medical Sciences

Diako8358@gmail.com+98 11 5262 4342

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026