The effect of adding fresh frozen plasma to the prime solution of the cardiopulmonary bypass pump on coagulation tests and patient return to the operating room

The effect of adding fresh frozen plasma to the prime solution of the cardiopulmonary bypass pump on coagulation tests and patient return to the operating room in patients undergoing coronary artery bypass graft surgery

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20251006067524N1

Enrollment

Registered

2025-11-10

Start date

2025-10-23

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Bypass Grafting. Atherosclerotic heart disease of native coronary artery without angina pectoris

Interventions

Intervention 1: Intervention group: Addition of plasma to the cardiopulmonary bypass pump prime during surgery, with the volume determined by the surgeon based on the prime volume (5 cc per kilogram)

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Patient's willingness to participate in the study Informed consent to participate in the study Age between 18 and 75 years Left ventricular ejection fraction greater than 30% No history of sternotomy or previous cardiac surgeries No history of liver, kidney, or pulmonary diseases No pacemaker implantation Not pregnant No history of allergy to fresh frozen plasma (FFP) No history of glucose-6-phosphate dehydrogenase (G6PD)

Exclusion criteria

Exclusion criteria: Pump time exceeding 120 minutes Cross-clamp time exceeding 100 minutes Use of ultrafiltration technique Reconnection of the patient to the cardiopulmonary bypass machine for any reason during surgery Presence of specific hematologic disorders

Design outcomes

Primary

Measure	Time frame
Laboratory parameters including hemoglobin, hematocrit, PT, PTT, and INR. Timepoint: After admission to the ICU and 24 hours after surgery. Method of measurement: Blood Test.;Patient's return to the operating room. Timepoint: Documentation of patient’s return to the operating room within 24 hours after surgery. Method of measurement: Check list.	—

Secondary

Measure	Time frame
Amount of received blood products. Timepoint: After admission to the ICU and 24 hours after surgery. Method of measurement: Checklist for documenting the amount of received blood products.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarshad Jalili Shahandashti

Shahid Rajaei Cardiovascular Research, Education, and Treatment Institute

jalilishfarshad@gmail.com+98 21 23921

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026