?????? ???? ?????. Atherosclerotic heart disease of native coronary artery
Conditions
Interventions
Intervention group: In this trial, patients who have defined indications for coronary angiography (at the discretion of the interventional cardiologist) will undergo invasive coronary angiography. In
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients with moderately stenotic (50%-70%) coronary lesions (non-Left main branch) in invasive coronary angiography who are candidates for physiologic assessment with FFR (Fractional Flow Reserve) measurement Informed and written consent by the patient in order to participate in the trial
Exclusion criteria
Exclusion criteria: Left main coronary lesion Acute or previous myocardial infarction in the past week Patients with acute decompensated heart failure Patients diagnosed with Heart failure (HF) and Left ventricular ejection fraction less than 35% Severe renal dysfunction (estimated Glomerular filtration rate (eGFR) less than 30 mL/min) according to Cockcroft-Gault formula Patients with systolic blood pressure less than 90 mm Hg and/or diastolic blood pressure less than 60 mm Hg More than one lesion in the evaluated target vessel Hypersensitivity to adenosine or any component of the formulation Sick sinus syndrome Second- or third-degree AV block Symptomatic bradycardia History of bronchoconstrictive or bronchospastic lung disease such as asthma Use of aminophylline/theophylline in the past 24 hours Use of dipyridamole Preexcited atrial fibrillation/flutter Hypersensitivity to nitroprusside or any component of the formulation Use of sildenafil/tadalafil in the past 72 hours Liver disease (cirrhosis, liver failure) History of Cerebrovascular accident (CVA) in the past month Anemia with Hemoglobin less than 11 mg/dL
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fractional Flow Reserve. Timepoint: Immediately after intracoronary injection of Adenosine and also immediately after intracoronary injection of Sodium Nitroprusside. Method of measurement: Intracoronary Pressure Guide Wire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse drug reactions. Timepoint: during and after intracoronary adenosine and nitroprusside injection. Method of measurement: Patient monitoring during and after drug injection. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMaryam Mehrpooya
Tehran University of Medical Sciences
Outcome results
None listed