Comparison of pain intensity following endodontic retreatment of mandibular molars with Gutta-Percha, Mineral Trioxide Aggregate (MTA), and Cold Ceramic: A randomized clinical trial

Evaluation of postoperative pain intensity after retreatment of mandibular molar teeth obturated with gutta-percha, Mineral Trioxide Aggregate (MTA), and Cold Ceramic

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20251003067492N1

Enrollment

Registered

2025-10-12

Start date

2025-11-16

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pain after retreatment of mandibular molar teeth.

Interventions

Intervention 1: Intervention group: Obturation with Gutta-Percha using Cold Lateral Compaction (CLC). Intervention 2: Intervention group: Obturation with Mineral Trioxide Aggregate (MTA) (Angelus, Bra

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients with asymptomatic mandibular molars requiring endodontic retreatment. Presence of periapical radiolucency on the target tooth. Patients aged over 18 years and under 60 years. Patients able and willing to provide informed consent.

Exclusion criteria

Exclusion criteria: Presence of uncontrolled systemic diseases. Presence of non-odontogenic or chronic pain.

Design outcomes

Primary

Measure	Time frame
Pain intensity after retreatment of mandibular molars obturated with three root canal filling materials: Gutta-percha, Mineral Trioxide Aggregate, and Cold Ceramic. Timepoint: 8, 24, 48, and 72 hours after treatment. Method of measurement: Visual Analog Scale (VAS) questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactErfan Ahmadyani

Sanandaj University of Medical Sciences

Ahmadyanierfan1@gmail.com+98 937 938 6232

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026