Morphea. Localized scleroderma [morphea]
Conditions
Interventions
Intervention 1: Intervention group: Hyaluronidase is injected on one side at a rate of 30 units per square centimeter (0.2 cc per square centimeter). To prepare hyalase, first dilute the 1500 unit via
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to No maximum
Inclusion criteria
Inclusion criteria: Willingness to participate in the study Has two relatively symmetrical sclerotic conditions Not using topical medications Patients who have been receiving systemic treatment with methotrexate or tofacitinib or mycophenolate mofetil for at least three months
Exclusion criteria
Exclusion criteria: Unwillingness to participate in the study History of allergy to lidocaine, hyalase, or bee stings Showing any complications or sensitivity after the injection Absence of symmetrical sclerotic lesions Receive topical medications
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Localized Scleroderma Cutaneous Assessment Tool(LoSCAT). Timepoint: Each patient is given three injections at one-month intervals and is followed up for six months during three sessions 0-3-6. During each visit, patients rate the improvement from the injections using a scoring system from zero to 10. Method of measurement: Two dermatologists with experience in morphea give patients a clinical score based on the severity and activity of morphea A during each visit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMahshid Ansari
Tehran University of Medical Sciences
Outcome results
None listed