Ventilator-Associated Pneumonia. Ventilator associated pneumonia
Conditions
Interventions
Intervention 1: Intervention group: This study is conducted in a double-blind manner. The patient and the person responsible for injecting the intervention drug are unaware of the type of allocation o
Sponsors
Arak University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Age between 18 and 80 years definite diagnosis of VAP based on CPIS criteria = 6 hospitalization in the Neurosurgery ICU of Valiasr Hospital absence of pulmonary or pneumonia before the start of ventilation absence of acute or chronic renal failure consumption of vitamin C in the past 48 hours absence of medica consumption of vitamin C in the past 48 hours other concomitant active factors (such as positive disease or blood) no CSF leak Informed consent from the patient or legal guardian
Exclusion criteria
Exclusion criteria: Change in diagnosis after enrollment in the study (i.e., lack of final confirmation of VAP) Occurrence of severe adverse events related to vitamin C during the study Patient or family’s willingness to withdraw from continued participation Death or transfer of the patient before completion of the intervention
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Duration of connection to the ventilation device. Timepoint: At the end of the study (one month later). Method of measurement: file.;Patient's radiography improved one month after vitamin C injection. Timepoint: At the end of the study (one month later). Method of measurement: file.;Length of stay. Timepoint: At the end of the study (one month later). Method of measurement: file.;Leukocytosis correction time. Timepoint: It is checked 5 times; once at the beginning of the study, the first 24 hours, 48 ??hours later, 72 and 96 hours later. Method of measurement: complete blood count.;CRP changes during the study. Timepoint: It is checked 5 times; once at the beginning of the study, the first 24 hours, 48 ??hours later, 72 and 96 hours later. Method of measurement: Measuring CRP in a patient's blood sample in the laboratory.;Mortality rate one month after vitamin C injection. Timepoint: At the end of the study (one month later). Method of measurement: file.;Length of stay in the ICU. Timepoint: At the end of the study (one month later). Method of measurement: file. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFatemeh Shojaa
Arak University of Medical Sciences
Outcome results
None listed