Evaluation and comparison of the effects of dexmedetomidine, metoprolol, and magnesium sulfate on postoperative bleeding control after craniotomy.

Comparison of the effects of dexmedetomidine, metoprolol, and magnesium sulfate on bleeding control after craniotomy and postoperative in patients with subdural and epidural hematoma undergoing emergency craniotomy

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20251002067466N1

Enrollment

Registered

2026-02-17

Start date

2025-11-22

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: epidural hematoma. Condition 2: subdural hematoma. Epidural hemorrhage Traumatic subdural hemorrhage

Interventions

Intervention 1: Intervention group: Dexmedetomidine group: Patients in this group will be injected with 1 microgram/kg of dexmedetomidine diluted in 5 cc of distilled water immediately after craniotom

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with subdural hematoma or epidural hematoma who are candidates for emergency craniotomy and admitted to Valiasr Hospital, Arak ASA physical status class I or II. No known hypersensitivity to metoral, dexmedetomidine, or magnesium sulfate Surgery performed by the same neurosurgeon Maximum surgical duration of 5 hours Absence of uncontrolled cardiac or pulmonary disease Absence of pulmonary disease

Exclusion criteria

Exclusion criteria: Lack of patient consent or cooperation All patients who die during surgery

Design outcomes

Primary

Measure	Time frame
Pulse rate. Timepoint: After the start of surgery, measurements will be recorded every 15 minutes, and subsequently in the recovery room as well as at 2, 4, 8, 12, and 24 hours postoperatively. Method of measurement: The variables will be monitored and recorded by the assigned medical intern using a checklist.;Respiratory rate. Timepoint: After the start of surgery, measurements will be recorded every 15 minutes, and subsequently in the recovery room as well as at 2, 4, 8, 12, and 24 hours postoperatively. Method of measurement: The variables will be monitored and recorded by the assigned medical intern using a checklist.;Systolic and diastolic blood pressure. Timepoint: After the start of surgery, measurements will be recorded every 15 minutes, and subsequently in the recovery room as well as at 2, 4, 8, 12, and 24 hours postoperatively. Method of measurement: The variables will be monitored and recorded by the assigned medical intern using a checklist.;02 saturation. Timepoint: After the start of surgery, measurements will be recorded every 15 minutes, and subsequently in the recovery room as well as at 2, 4, 8, 12, and 24 hours postoperatively. Method of measurement: The variables will be monitored and recorded by the assigned medical intern using a checklist.;Number of pack cell received. Timepoint: after the surgery. Method of measurement: They will be documented by the nurses in the ICU sheets after surgery and subsequently evaluated.;Number of platelet units received. Timepoint: after the surgery. Method of measurement: They will be documented by the nurses in the ICU sheets after surgery and subsequently evaluated.;Number of FFP units received. Timepoint: after the surgery. Method of measurement: They will be documented by the nurses in the ICU sheets after surgery and subsequently evaluated.;Average return to operating room. Timepoint: after the surgery. Method of measurement: The frequency of return to the operating room will be recorded by the assigned me	—

Measure

Time frame

Pulse rate. Timepoint: After the start of surgery, measurements will be recorded every 15 minutes, and subsequently in the recovery room as well as at 2, 4, 8, 12, and 24 hours postoperatively. Method of measurement: The variables will be monitored and recorded by the assigned medical intern using a checklist.;Respiratory rate. Timepoint: After the start of surgery, measurements will be recorded every 15 minutes, and subsequently in the recovery room as well as at 2, 4, 8, 12, and 24 hours postoperatively. Method of measurement: The variables will be monitored and recorded by the assigned medical intern using a checklist.;Systolic and diastolic blood pressure. Timepoint: After the start of surgery, measurements will be recorded every 15 minutes, and subsequently in the recovery room as well as at 2, 4, 8, 12, and 24 hours postoperatively. Method of measurement: The variables will be monitored and recorded by the assigned medical intern using a checklist.;02 saturation. Timepoint: After the start of surgery, measurements will be recorded every 15 minutes, and subsequently in the recovery room as well as at 2, 4, 8, 12, and 24 hours postoperatively. Method of measurement: The variables will be monitored and recorded by the assigned medical intern using a checklist.;Number of pack cell received. Timepoint: after the surgery. Method of measurement: They will be documented by the nurses in the ICU sheets after surgery and subsequently evaluated.;Number of platelet units received. Timepoint: after the surgery. Method of measurement: They will be documented by the nurses in the ICU sheets after surgery and subsequently evaluated.;Number of FFP units received. Timepoint: after the surgery. Method of measurement: They will be documented by the nurses in the ICU sheets after surgery and subsequently evaluated.;Average return to operating room. Timepoint: after the surgery. Method of measurement: The frequency of return to the operating room will be recorded by the assigned me

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAlireza Kamali

Arak University of Medical Sciences

Alikamaliir@yahoo.com+98 86 3222 2003

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026