• Intrauterine Growth Restriction (IUGR)• High-Risk Pregnancy. Maternal care for known or suspected poor fetal growth
Conditions
Interventions
Intervention 1: Intervention group: Participants will receive a daily oral low-dose aspirin 81 mg, taken once nightly, plus one oral omega-3 capsule 1000 mg (containing EPA and DHA). The intervention
Sponsors
Sanandaj University of Medical Sciences
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: PAPP A level less than 0.5 MoM in first trimester screening double marker test Gestational age between 12 and 16 weeks Presence of risk factors associated with intrauterine growth restriction such as history of preeclampsia or fetal weight below the tenth percentile in a previous pregnancy or chronic hypertension Singleton pregnancy Written informed consent from the mother to participate in the study
Exclusion criteria
Exclusion criteria: Presence of chronic underlying diseases such as diabetes, renal, or cardiac disorders Presence of structural or chromosomal abnormalities in the fetus Regular use of omega-3 supplements or anticoagulant medications prior to enrollment in the study Multiple pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Estimated fetal weight based on biometric parameters including head circumference, abdominal circumference, and femur length. Timepoint: At baseline, at twenty-eight weeks of gestation, and at thirty-six weeks of gestation. Method of measurement: Fetal ultrasound performed by a perinatology specialist using Doppler ultrasound equipment.;Doppler indices of the uterine artery and umbilical artery including vascular resistance and systolic to diastolic ratio. Timepoint: At baseline, at twenty-eight weeks of gestation, and at thirty-six weeks of gestation. Method of measurement: Color Doppler ultrasound performed by a perinatology specialist using standard ultrasound equipment.;Incidence of intrauterine growth restriction defined as fetal weight below the tenth percentile for gestational age. Timepoint: At twenty-eight weeks of gestation and at thirty-six weeks of gestation. Method of measurement: Fetal biometry ultrasound and assessment using standard fetal growth charts by a perinatology specialist.;Placental vascular resistance assessed by uterine artery resistance index. Timepoint: At baseline, at twenty-eight weeks, and at thirty-six weeks. Method of measurement: Uterine artery Doppler ultrasonography performed by a perinatology specialist.;Neonatal birth weight at delivery. Timepoint: At delivery. Method of measurement: Measurement using a digital neonatal scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Rate of neonatal admission to the neonatal intensive care unit. Timepoint: During the postnatal hospital stay until discharge. Method of measurement: NICU admission recorded from hospital records and reason for admission. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAfsaneh Partoandazanpour
Sanandaj University of Medical Sciences
Outcome results
None listed